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CAS 9001-15-4

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Creatine kinase

Description:
Creatine kinase (CK), with the CAS number 9001-15-4, is an enzyme that plays a crucial role in energy metabolism, particularly in muscle and brain tissues. It catalyzes the reversible transfer of a phosphate group from ATP (adenosine triphosphate) to creatine, forming phosphocreatine and ADP (adenosine diphosphate). This reaction is vital for maintaining energy homeostasis during periods of high energy demand, such as muscle contraction. Creatine kinase exists in several isoforms, primarily CK-MM (found in skeletal muscle), CK-MB (found in the heart), and CK-BB (found in the brain). The enzyme is typically present in the cytosol of cells and can also be found in mitochondria. Its activity can be measured in clinical settings to assess muscle damage or myocardial infarction, as elevated levels of CK in the bloodstream can indicate tissue injury. Creatine kinase is a dimeric enzyme, composed of two subunits, and its activity is influenced by factors such as pH, temperature, and the concentration of substrates and products.
Formula:Unspecified
Synonyms:
  • ATP:creatine N-phosphotransferase
  • ATP:creatine phosphotransferase
  • CK
  • Creatine Kinase
  • Creatine kinase (CK-BB iso-enzyme) (catalytic concentration)
  • Creatine kinases
  • Creatine phosphokinase
  • Creatine phosphokinases
  • Creatine phosphotransferase
  • Creatine phosphotransferases
  • See more synonyms
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