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CAS 9001-25-6

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Blood-coagulation factor VII

Description:
Blood-coagulation factor VII, also known as proconvertin, is a glycoprotein that plays a crucial role in the coagulation cascade, which is essential for blood clotting. It is synthesized in the liver and is activated by tissue factor (TF) in the presence of calcium ions, leading to the conversion of factor X to Xa, which subsequently promotes the formation of a fibrin clot. Factor VII is a vitamin K-dependent protein, meaning its synthesis requires vitamin K for the post-translational modification of certain glutamic acid residues, which is vital for its activity. Deficiencies or dysfunctions in factor VII can lead to bleeding disorders, while excessive activity may contribute to thrombotic conditions. The CAS number 9001-25-6 identifies this protein in chemical databases, facilitating research and clinical applications. Factor VII can also be used therapeutically in patients with hemophilia or other bleeding disorders, highlighting its importance in both physiology and medicine.
Formula:Unspecified
Synonyms:
  • Blood clotting factor VII
  • Blood coagulation factor VIIc
  • Blut-Koagulationsfaktor VII
  • Coagulation factor VII
  • F7 coagulation factor VII
  • Factor VII
  • Proconvertin
  • Serine protease factor 7
  • Serum prothrombin conversion accelerators
  • facteur VII de la coagulation sanguine
  • See more synonyms
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