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CAS 9001-27-8

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Blood-coagulation factor VIII

Description:
Blood-coagulation factor VIII, also known as antihemophilic factor, is a crucial glycoprotein involved in the coagulation cascade, specifically in the intrinsic pathway of blood coagulation. It is essential for normal blood clotting and plays a significant role in hemostasis. Factor VIII is synthesized primarily in the liver and is released into the bloodstream, where it circulates in an inactive form. Upon activation, it interacts with factor IXa and factor X, facilitating the conversion of prothrombin to thrombin, which ultimately leads to the formation of a fibrin clot. Deficiencies or dysfunctions in factor VIII can lead to hemophilia A, a genetic bleeding disorder characterized by prolonged bleeding and difficulty in clot formation. The protein is composed of multiple domains, which contribute to its stability and function, and it is typically measured in international units (IU) in clinical settings. Factor VIII is also used therapeutically in hemophilia treatment, where it is administered to restore adequate levels of the factor in affected individuals.
Formula:Unspecified
Synonyms:
  • AHF
  • AHG
  • Actif VIII
  • Ahf-A
  • Ahf-Hp
  • Alphanate
  • Amofil
  • Amtihaemophilic factor
  • Antihaemophiler faktor A
  • Antihaemophiles globulin
  • See more synonyms
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