CAS 9001-28-9

Blood-coagulation factor IX, also known as Christmas factor, is a glycoprotein that plays a crucial role in the coagulation cascade, specifically in the intrinsic pathway of blood coagulation. It is synthesized primarily in the liver and is essential for the conversion of factor X to its active form, factor Xa, which subsequently leads to the formation of a fibrin clot. Factor IX is activated by factor XIa or by the tissue factor-factor VIIa complex, and its activity is dependent on the presence of calcium ions. Deficiency in factor IX leads to hemophilia B, a genetic disorder characterized by prolonged bleeding. The protein is composed of several domains, including a Gla domain that binds calcium, facilitating its interaction with phospholipid membranes. Factor IX is typically administered as a therapeutic agent in hemophilia treatment, often derived from recombinant DNA technology or human plasma. Its stability and activity can be influenced by factors such as pH, temperature, and the presence of other ions or proteins in the solution.