Glutamate dehydrogenase (GDH) is an important enzyme that catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate, utilizing NAD+ or NADP+ as a cofactor. This enzyme plays a crucial role in amino acid metabolism and the regulation of nitrogen balance in organisms. GDH is found in various tissues, particularly in the liver and brain, and is involved in the urea cycle and the synthesis of neurotransmitters. The enzyme's activity is influenced by several factors, including pH, temperature, and the concentrations of substrates and products. GDH exists in different isoforms, which may vary in their kinetic properties and regulatory mechanisms. Its activity can be modulated by allosteric effectors, such as ADP and GTP, reflecting the energy status of the cell. Due to its significance in metabolic pathways, GDH is of interest in various fields, including biochemistry, medicine, and biotechnology, particularly in the context of metabolic disorders and neurodegenerative diseases.

Glutamate dehydrogenase

9001-46-1: Glutamate dehydrogenase (GDH) is an important enzyme that catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate, utilizing NAD+ or NADP+ as a cofactor. This enzyme plays a crucial role in amino acid metabolism and the regulation of nitrogen balance in organisms. GDH is found in various tissues, particularly in the liver and brain, and is involved in the urea cycle and the synthesis of neurotransmitters. The enzyme's activity is influenced by several factors, including pH, temperature, and the concentrations of substrates and products. GDH exists in different isoforms, which may vary in their kinetic properties and regulatory mechanisms. Its activity can be modulated by allosteric effectors, such as ADP and GTP, reflecting the energy status of the cell. Due to its significance in metabolic pathways, GDH is of interest in various fields, including biochemistry, medicine, and biotechnology, particularly in the context of metabolic disorders and neurodegenerative diseases.

<p>Glutamate dehydrogenase, an enzyme found in prokaryotes and eukaryotic mitochondria, facilitates the enzymatic determination of ammonia, alpha-ketoglutaric acid</p>

CAS 9001-46-1

Glutamate dehydrogenase

Glutamate dehydrogenase

Ref: TM-T78350