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CAS 9001-51-8

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Hexokinase

Description:
Hexokinase is an enzyme that plays a crucial role in cellular metabolism, specifically in the phosphorylation of glucose to form glucose-6-phosphate, which is a key step in glycolysis. It is classified as a transferase, which means it facilitates the transfer of a phosphate group from ATP to glucose. Hexokinase is found in various tissues throughout the body, including the liver, brain, and muscle, and exists in multiple isoforms, each with distinct regulatory properties and tissue distributions. The enzyme operates optimally under physiological conditions and is characterized by its high affinity for glucose, allowing it to effectively catalyze the reaction even at low glucose concentrations. Hexokinase activity is tightly regulated by the availability of substrates and products, as well as by allosteric effectors, ensuring that glucose metabolism is finely tuned to the energy needs of the cell. Its dysfunction can lead to metabolic disorders, highlighting its importance in maintaining glucose homeostasis.
Formula:Unspecified
Synonyms:
  • ATP-<span class="text-smallcaps">D</span>-hexose 6-phosphotransferase
  • ATP-D-hexose 6-phosphotransferase
  • ATP-dependent hexokinase
  • E.C. 2.7.1.1
  • Glucokinase
  • Glucose ATP phosphotransferase
  • HK1 hexokinase 1
  • Hexokinase
  • Hexokinase 1
  • Hexokinase D
  • See more synonyms
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