Monoamine oxidase (MAO) is an enzyme that plays a crucial role in the metabolism of neurotransmitters in the brain, specifically by catalyzing the oxidative deamination of monoamines such as serotonin, norepinephrine, and dopamine. It exists in two isoforms, MAO-A and MAO-B, each with distinct substrate specificities and tissue distributions. MAO is primarily located in the outer mitochondrial membrane of cells and is involved in regulating mood, emotion, and various physiological processes. The enzyme's activity can be influenced by various factors, including genetic variations, dietary components, and certain medications. Inhibitors of monoamine oxidase (MAOIs) are used therapeutically to treat depression and anxiety disorders, as they increase the levels of monoamines in the synaptic cleft. However, the use of MAOIs requires dietary restrictions to avoid hypertensive crises due to interactions with tyramine-rich foods. Overall, MAO is essential for maintaining neurotransmitter balance and has significant implications in neuropharmacology and mental health.

Monoamine oxidase

9001-66-5: Monoamine oxidase (MAO) is an enzyme that plays a crucial role in the metabolism of neurotransmitters in the brain, specifically by catalyzing the oxidative deamination of monoamines such as serotonin, norepinephrine, and dopamine. It exists in two isoforms, MAO-A and MAO-B, each with distinct substrate specificities and tissue distributions. MAO is primarily located in the outer mitochondrial membrane of cells and is involved in regulating mood, emotion, and various physiological processes. The enzyme's activity can be influenced by various factors, including genetic variations, dietary components, and certain medications. Inhibitors of monoamine oxidase (MAOIs) are used therapeutically to treat depression and anxiety disorders, as they increase the levels of monoamines in the synaptic cleft. However, the use of MAOIs requires dietary restrictions to avoid hypertensive crises due to interactions with tyramine-rich foods. Overall, MAO is essential for maintaining neurotransmitter balance and has significant implications in neuropharmacology and mental health.

<p>Enzyme that breaks down amines in the brain and body, affecting mood and brain function.</p>

CAS 9001-66-5

Monoamine oxidase

Monoamine oxidase

Ref: TM-T75422