Plasminogen is a glycoprotein that plays a crucial role in the fibrinolytic system, which is responsible for the breakdown of fibrin in blood clots. It is synthesized primarily in the liver and circulates in the bloodstream as an inactive precursor to plasmin, the enzyme that dissolves fibrin. Plasminogen is characterized by its molecular weight, which varies due to glycosylation, and it contains multiple kringle domains that are essential for its interaction with fibrin and other proteins. Upon activation, typically by tissue plasminogen activator (tPA) or urokinase, plasminogen is converted to plasmin, facilitating clot lysis. The regulation of plasminogen activation is critical for maintaining hemostasis and preventing excessive bleeding or thrombosis. Additionally, plasminogen has been implicated in various physiological and pathological processes, including wound healing, inflammation, and cancer metastasis. Its clinical significance is underscored by its use as a biomarker in certain conditions and its potential therapeutic applications in managing thrombotic disorders.

Plasminogen

9001-91-6: Plasminogen is a glycoprotein that plays a crucial role in the fibrinolytic system, which is responsible for the breakdown of fibrin in blood clots. It is synthesized primarily in the liver and circulates in the bloodstream as an inactive precursor to plasmin, the enzyme that dissolves fibrin. Plasminogen is characterized by its molecular weight, which varies due to glycosylation, and it contains multiple kringle domains that are essential for its interaction with fibrin and other proteins. Upon activation, typically by tissue plasminogen activator (tPA) or urokinase, plasminogen is converted to plasmin, facilitating clot lysis. The regulation of plasminogen activation is critical for maintaining hemostasis and preventing excessive bleeding or thrombosis. Additionally, plasminogen has been implicated in various physiological and pathological processes, including wound healing, inflammation, and cancer metastasis. Its clinical significance is underscored by its use as a biomarker in certain conditions and its potential therapeutic applications in managing thrombotic disorders.

<p>Plasminogen is a molecule that is involved in the blood clotting cascade. It is an important component of fibrin and binds calcium ions. Plasminogen can be modified by tissue plasminogen activator (tPA) to form plasmin, which degrades fibrin clots. Magnetic nanoparticles conjugated with monoclonal antibodies have been shown to inhibit the activity of plasminogen and show promise as a therapy for infarction. The fluorescence spectroscopy technique known as dichroism has also been used to study the structure and function of plasminogen molecules.</p>

CAS 9001-91-6

Plasminogen

Plasminogen from human plasma

Ref: 3D-JAA00191