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CAS 9002-04-4

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Thrombin

Description:
Thrombin, with the CAS number 9002-04-4, is a serine protease enzyme that plays a crucial role in the coagulation cascade, facilitating blood clotting. It is produced from prothrombin, a plasma protein, and is primarily found in platelets and plasma. Thrombin catalyzes the conversion of fibrinogen to fibrin, which is essential for the formation of a stable blood clot. This enzyme exhibits specificity for peptide bonds adjacent to arginine residues, which is characteristic of serine proteases. Thrombin also has additional functions, including activating platelets and influencing various cellular processes such as inflammation and wound healing. It is typically used in clinical settings for its anticoagulant properties and in research for studying coagulation mechanisms. Thrombin is sensitive to temperature and pH, which can affect its activity and stability. As a therapeutic agent, it is important to handle thrombin with care, considering its potent biological effects and the potential for inducing thrombotic events if not properly regulated.
Formula:Unspecified
Synonyms:
  • Blood-coagulation factor II, activated
  • Blood-coagulation factor IIa
  • Bovine thrombin
  • Bp 25432
  • E.C. 3.4.21.5
  • E.C. 3.4.4.13
  • Evithrom
  • Factor 2a
  • Factor IIa
  • Thrombase
  • See more synonyms
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