CAS 900515-16-4

2,4-Thiazolidinedione,5-[[5-(4-fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-, (5Z)-

Description:

2,4-Thiazolidinedione, 5-[[5-(4-fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-, (5Z)- is a synthetic organic compound characterized by its thiazolidinedione core, which is a five-membered ring containing sulfur and nitrogen. This compound features a substituted furan moiety and a fluorinated phenolic group, contributing to its potential biological activity. The presence of the thiazolidinedione structure suggests that it may interact with peroxisome proliferator-activated receptors (PPARs), which are involved in glucose and lipid metabolism, making it of interest in diabetes research. The fluorine atom in the phenolic ring can enhance lipophilicity and metabolic stability, potentially influencing the compound's pharmacokinetic properties. Additionally, the hydroxyl group on the phenyl ring may participate in hydrogen bonding, affecting solubility and reactivity. Overall, this compound's unique structural features may confer specific biological activities, warranting further investigation in medicinal chemistry and pharmacology.

Formula: C₁₄H₈FNO₄S

Synonyms:

• As 252424
• (5Z)-5-{[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione
• 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

(5Z)-5-{[5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione

CAS: 900515-16-4

Formula: C₁₄H₈FNO₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 305.2810

Ref: IN-DA0036ZS

AS-252424

CAS: 900515-16-4

AS-252424

Purity: ≥98%

Molecular weight: 305.28g/mol

Ref: 54-BUP12547

AS-252424

CAS: 900515-16-4

AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.

Formula: C₁₄H₈FNO₄S

Purity: 99.06% - 99.09%

Color and Shape: Solid

Molecular weight: 305.28

Ref: TM-T6208

AS-252424

CAS: 900515-16-4

Formula: C₁₄H₈FNO₄S

Molecular weight: 305.28

Ref: 7W-GL6666

AS-252424

Controlled Product

CAS: 900515-16-4

Applications AS-252424 is a novel, potent, and selective phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor. It is also an inhibitor of Casein kinase and PI3K p110α.
References Pomel, V., et al.: J. Med. Chem., 49, 3857 (2006); Edling, C.E., et al.: Clin. Cancer Res., 16, 4928 (2010); Condliffe, A.M., et al.: Blood, 106, 1432 (2005)

Formula: C₁₄H₈FNO₄S

Color and Shape: Neat

Molecular weight: 305.28

Ref: TR-A780000

AS 252424

CAS: 900515-16-4

Inhibitor of PI3K? kinase

Formula: C₁₄H₈FNO₄S

Purity: Min. 95%

Molecular weight: 305.28 g/mol

Ref: 3D-FA101250