CAS 90053-19-3

Guanosine 5'-(tetrahydrogen triphosphate), 3'-amino-2',3'-dideoxy-

Description:

Guanosine 5'-(tetrahydrogen triphosphate), 3'-amino-2',3'-dideoxy- is a nucleotide analog that plays a significant role in biochemical research, particularly in studies involving nucleic acid synthesis and enzyme interactions. This compound features a guanine base linked to a ribose sugar, which is further connected to a triphosphate group. The presence of the 3'-amino and 2',3'-dideoxy modifications distinguishes it from natural nucleotides, impacting its reactivity and interaction with enzymes such as polymerases. These modifications can enhance its stability and resistance to degradation by nucleases, making it a valuable tool in molecular biology applications, including the development of antiviral therapies and the study of RNA and DNA processes. The CAS number 90053-19-3 uniquely identifies this compound, facilitating its recognition in scientific literature and databases. Overall, its structural characteristics contribute to its utility in various biochemical and pharmacological contexts.

Formula: C₁₀H₁₇N₆O₁₂P₃

3'-Amino-2',3'-dideoxyguanosine-5'-triphosphate lithium salt - 100 mM aqueous solution

CAS: 90053-19-3

3'-Amino-2',3'-dideoxyguanosine's lack of a 3'-hydroxyl group makes it a chain terminator for DNA polymerase, a key application in Sanger sequencing. Additionally, the 3'-amino group serves as a functional handle for modifying the 3' end of oligonucleotides with various labels or conjugates, expanding their utility in research and diagnostics. The lithium salt ensures better handling and solubility.

Formula: C₁₀H₁₇N₆O₁₂P₃(freeacid)

Purity: Min. 95%

Color and Shape: Clear Liquid

Molecular weight: 506.2 g/mol

Ref: 3D-NA71666