CAS 9009-65-8

Protamine sulfate

Description:

Protamine sulfate is a polypeptide derived from fish sperm, primarily used as an anticoagulant antagonist to reverse the effects of heparin, a common anticoagulant medication. It is composed of a mixture of protamines, which are rich in arginine and have a high positive charge, allowing them to bind effectively to negatively charged heparin molecules. This interaction neutralizes heparin's anticoagulant properties, making protamine sulfate essential in clinical settings, particularly during surgeries or procedures requiring rapid reversal of heparin. The substance is typically administered intravenously and has a relatively short half-life, necessitating careful dosing and monitoring. Protamine sulfate can also induce allergic reactions in some patients, particularly those with fish allergies, and its use requires caution in individuals with a history of hypersensitivity. Additionally, it may cause side effects such as hypotension and bradycardia if administered too rapidly. Overall, protamine sulfate plays a critical role in managing anticoagulation during medical procedures.

Formula: Unspecified

Synonyms:

• Novo protamine sulfate
• Novoprotamine sulfate
• Protamine sulfate
• Protamine sulfates
• Protamines, sulfates

PROTAMINE SULFATE CRS

CAS: 9009-65-8

PROTAMINE SULFATE CRS

Ref: 41-Y0002179

Protamine Sulfate

CAS: 9009-65-8

Xtracts of glands or other orgs or secretions extracts of glands or other organs or of their secretions

Color and Shape: White Off-White Crystalline Powder

Ref: 45-1578612

Protamine sulfate

CAS: 9009-65-8

Protamine sulfate: polycationic peptide, antiheparin, neutralizes anticoagulant effect, aids gene transfer.

Purity: 99.87%

Color and Shape: Solid

Ref: TM-T41031

Protamine sulfate

CAS: 9009-65-8

Protamine sulfate is a fusogenic protein that is used to maintain the pH balance in the blood. It binds to hematopoietic cells and inhibits their uptake by macrophages, which reduces the removal of immune complexes. Protamine sulfate can also inhibit erythrocyte aggregation and reduce the production of reactive oxygen species. Protamine sulfate has been shown to be effective in vitro against HIV infection and fusogenic viruses such as influenza virus and herpes simplex virus. Protamine sulfate has also been shown to be effective in vivo for the treatment of autoimmune diseases such as multiple sclerosis.

Color and Shape: White Powder

Ref: 3D-FP30984

Protamine Sulfate for molecular biology, 90-110%

CAS: 9009-65-8

Purity: 90.0-110.0%

Color and Shape: White to almost white, Powder, Clear, Colourless

Molecular weight: 372.42

Ref: SR-78349