CAS 9010-34-8

Thyroglobulin

Description:

Thyroglobulin is a glycoprotein produced by the thyroid gland, primarily functioning as a precursor to thyroid hormones, namely thyroxine (T4) and triiodothyronine (T3). It is composed of two identical subunits and contains a high proportion of tyrosine residues, which are crucial for hormone synthesis. Thyroglobulin is stored in the colloid of thyroid follicles and is released into the bloodstream upon stimulation by thyroid-stimulating hormone (TSH). Its molecular weight can vary significantly due to glycosylation, typically ranging from 660,000 to over 1,000,000 daltons. In clinical settings, thyroglobulin levels are measured as a tumor marker for thyroid cancer, particularly after thyroidectomy, as it can indicate residual or recurrent disease. Additionally, it plays a role in the regulation of iodine uptake and metabolism within the thyroid. Thyroglobulin is soluble in water and exhibits stability under physiological conditions, making it an important biomolecule in both endocrine function and medical diagnostics.

Formula: Unspecified

Synonyms:

• Proloid
• Thyroglobulins
• Elityran
• Globulins, thyro
• Thyroglobulin

Thyroglobulin for Molar Mass Determination (Thyroglobulin)

CAS: 9010-34-8

Hormones, prostaglandins, thromboxanes and leukotrienes, natural or synthetic; derivatives and analogues thereof, etc, nesoi

Color and Shape: White Yellow Powder

Ref: 45-1666032

Thyroglobulin

CAS: 9010-34-8

Thyroglobulin is a glycoprotein that is synthesized in the thyroid gland and is released into the bloodstream. The molecule has two polypeptide chains, one of which contains copper ions. Thyroglobulin binds to iodine and produces a light signal when illuminated with an ultraviolet light source. Thyroglobulin can also be used as a marker for the diagnosis of thyroid cancer and other disorders such as bowel disease or cell nuclei. Thyroglobulin is an inhibitor of squamous carcinoma cells in culture and can inhibit the growth of colorectal cancer cells in mice by interfering with vascular endothelial growth factor receptor-2 (VEGFR-2) signaling pathways. Thyroglobulin also inhibits proliferation of colon cancer cells through suppression of nuclear factor-kappa B (NF-κB) signaling pathways.

Purity: 90%Min

Color and Shape: Powder

Ref: 3D-JAA01034