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CAS 9012-90-2

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DNA-dependent DNA polymerase

Description:
DNA-dependent DNA polymerase, with the CAS number 9012-90-2, is an essential enzyme involved in DNA replication and repair processes in living organisms. This enzyme synthesizes new DNA strands by adding nucleotides complementary to a template strand, utilizing deoxyribonucleoside triphosphates (dNTPs) as substrates. It operates in a 5' to 3' direction, meaning it adds nucleotides to the growing DNA strand at the 3' end. DNA polymerase requires a primer to initiate synthesis, as it cannot start a new strand de novo. The enzyme is characterized by its high fidelity, ensuring accurate replication of genetic material, which is crucial for maintaining genomic integrity. Additionally, DNA polymerases exhibit proofreading activity, allowing them to correct errors during DNA synthesis. These enzymes are vital in various biological processes, including cell division, DNA repair, and the synthesis of genomic DNA in viruses. Their activity is influenced by factors such as temperature, pH, and the presence of cofactors or inhibitors, making them a focus of study in molecular biology and biotechnology.
Formula:Unspecified
Synonyms:
  • AccuPrimePfx
  • AcycloPol
  • AmpliTaq Gold polymerase
  • Amplitaq
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA polymerase
  • DNA polymerase α
  • DNA polymerase ε
  • DNA replicase
  • See more synonyms
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  • DNA polymerase

    CAS:
    DNA polymerase is an essential enzymatic protein, derived from various organisms including bacteria, archaea, and eukaryotes, which plays a pivotal role in the replication and repair of DNA. This enzyme functions by adding nucleotides to the growing DNA strand in a template-dependent manner, ensuring the accurate duplication of the genetic material. It operates through a polymerization mechanism, where nucleotides are selected and incorporated complementary to the template strand, facilitating the elongation of the new DNA strand in the 5' to 3' direction.

    Ref: 3D-JAA01290

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