CAS 90139-06-3

Cilazaprilat

Description:

Cilazaprilat is the active metabolite of cilazapril, an angiotensin-converting enzyme (ACE) inhibitor used primarily in the treatment of hypertension and heart failure. It is characterized by its ability to inhibit the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure. Cilazaprilat is a white to off-white crystalline powder that is soluble in water and exhibits a moderate lipophilicity. Its chemical structure includes a carboxyl group, which is essential for its biological activity. The substance has a relatively long half-life, allowing for once-daily dosing in clinical settings. Cilazaprilat is typically administered orally and is known for its efficacy in managing cardiovascular conditions. As with other ACE inhibitors, potential side effects may include cough, hyperkalemia, and hypotension, particularly in patients with renal impairment. Overall, cilazaprilat is an important therapeutic agent in the management of hypertension and heart failure, contributing to improved patient outcomes.

Formula: C₂₀H₂₇N₃O₅

InChI: InChI=1S/C20H27N3O5/c24-18-15(8-4-12-22-13-5-9-17(20(27)28)23(18)22)21-16(19(25)26)11-10-14-6-2-1-3-7-14/h1-3,6-7,15-17,21H,4-5,8-13H2,(H,25,26)(H,27,28)/t15-,16-,17-/m0/s1

InChI key: InChIKey=UVAUYSRYXACKSC-ULQDDVLXSA-N

SMILES: C(O)(=O)[C@H]1N2N(CCC1)CCC[C@H](N[C@@H](CCC3=CC=CC=C3)C(O)=O)C2=O

Synonyms:

• (1S,9S)-9-[[(1S)-1-Carboxy-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
• (1S,9S)-9-{[(1S)-1-Carboxy-3-phenylpropyl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
• 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[(1-carboxy-3-phenylpropyl)amino]octahydro-10-oxo-, [1S-[1α,9α(R*)]]-
• 6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-carboxy-3-phenylpropyl]amino]octahydro-10-oxo-, (1S,9S)-
• 90139-06-3
• Ro 31-3113
• Cilazaprilat

Cilazapril EP Impurity B (Cilazaprilat)

CAS: 90139-06-3

Formula: C₂₀H₂₇N₃O₅

Color and Shape: White To Off-White Solid

Molecular weight: 389.45

Ref: 4Z-C-062

Cilazaprilat-d5

CAS: 90139-06-3

Formula: C₂₀H₂₂D₅N₃O₅

Molecular weight: 394.48

Ref: 4Z-C-064

Cilazaprilat

Controlled Product

CAS: 90139-06-3

Applications The active metabolite of Cilazapril. An ACE inhibitor. Antihypertensive.
References Natoff, I.L., et al.: J. Cardiovasc. Pharmacol., 7, 569 (1985), Szucs, T., et al.: Drugs, 41, Suppl.1, 18 (1991), Pordy, R.C., et al.: Cardiology, 86, 41 (1995),

Formula: C₂₀H₂₇N₃O₅

Color and Shape: Off-White

Molecular weight: 389.45

Ref: TR-C441210

Cilazaprilat

CAS: 90139-06-3

Inhibitor of angiotensin converting enzyme

Formula: C₂₀H₂₇N₃O₅

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 389.45 g/mol

Ref: 3D-FC20434

Cilazaprilat-d5

Controlled Product

CAS: 90139-06-3

Applications Isotope labelled analogue of Cilazaprilat (C441210), the active metabolite of Cilazapril (C441200). Cilazaprilat is an ACE inhibitor and antihypertensive agent.
References Natoff, I.L., et al.: J. Cardiovasc. Pharmacol., 7, 569 (1985), Szucs, T., et al.: Drugs, 41, Suppl.1, 18 (1991), Pordy, R.C., et al.: Cardiology, 86, 41 (1995),

Formula: C₂₀D₅H₂₂N₃O₅

Color and Shape: Neat

Molecular weight: 394.476

Ref: TR-C441212

Cilazapril EP Impurity B

CAS: 90139-06-3

Formula: C₂₀H₂₇N₃O₅

Molecular weight: 389.45

Ref: ST-EA-CP-C107009

Cilazaprilat

CAS: 90139-06-3

Cilazaprilat is the active metabolite of cilazapril, a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

Formula: C₂₀H₂₇N₃O₅

Color and Shape: Solid

Molecular weight: 389.45

Ref: TM-T68412