Neocarzinostatin is a potent antitumor antibiotic derived from the bacterium *Streptomyces carzinostaticus*. It is classified as a chromoprotein and is known for its ability to induce DNA damage, making it effective in cancer treatment. The substance exhibits a complex structure, featuring a chromophore that is responsible for its biological activity. Neocarzinostatin operates primarily by intercalating into DNA and generating free radicals, leading to strand breaks and ultimately inhibiting cellular replication. This mechanism of action is particularly effective against rapidly dividing cancer cells. In terms of solubility, neocarzinostatin is typically soluble in water and exhibits stability under certain conditions, although it can be sensitive to light and temperature. Its therapeutic applications have been explored in various malignancies, and it is often studied in combination with other chemotherapeutic agents to enhance efficacy and reduce resistance. As with many chemotherapeutics, careful consideration of dosage and potential side effects is essential in clinical settings.

Neocarzinostatin was found in the culture broth of Streptomyces carzinostaticus by Ishida et al. of Tohoku University in 1957. It showed strong cytotoxicity against sarcoma 180 ascites, tumor cells, and leukemia SN36. Neocarzinostatin was found to be an acidic peptide of Mr 10700, consisting of 109 amino acid residues. Recently the principal agent of anticancer and antibacterial activity in neocarzinostatin was found to be a small molecular chromophore with the peptide component playing a role by stabilizing the chromophore in vivo. Neocarzinostatin is used to treat leukemia and gastric and pancreatic cancer.

Neocarzinostatin

9014-02-2: Neocarzinostatin is a potent antitumor antibiotic derived from the bacterium *Streptomyces carzinostaticus*. It is classified as a chromoprotein and is known for its ability to induce DNA damage, making it effective in cancer treatment. The substance exhibits a complex structure, featuring a chromophore that is responsible for its biological activity. Neocarzinostatin operates primarily by intercalating into DNA and generating free radicals, leading to strand breaks and ultimately inhibiting cellular replication. This mechanism of action is particularly effective against rapidly dividing cancer cells. In terms of solubility, neocarzinostatin is typically soluble in water and exhibits stability under certain conditions, although it can be sensitive to light and temperature. Its therapeutic applications have been explored in various malignancies, and it is often studied in combination with other chemotherapeutic agents to enhance efficacy and reduce resistance. As with many chemotherapeutics, careful consideration of dosage and potential side effects is essential in clinical settings.

<p>Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic.</p>

CAS 9014-02-2

Neocarzinostatin

Neocarzinostatin

Ref: TM-T16283