Thrombopoietin (TPO) is a glycoprotein hormone primarily produced by the liver and kidneys, playing a crucial role in the regulation of platelet production in the bone marrow. It functions by stimulating the proliferation and differentiation of megakaryocyte progenitor cells, which are responsible for producing platelets. TPO binds to the thrombopoietin receptor (MPL) on these progenitor cells, activating signaling pathways that promote cell survival and maturation. The substance is characterized by its relatively large molecular weight and complex glycosylation patterns, which are essential for its biological activity and stability. Thrombopoietin levels in the bloodstream are tightly regulated, with increased levels typically observed in response to low platelet counts. Dysregulation of TPO can lead to various hematological disorders, including thrombocytopenia and thrombocytosis. As a therapeutic agent, recombinant TPO or TPO mimetics are being explored for their potential in treating conditions associated with low platelet counts. Overall, TPO is a vital component of hematopoiesis and plays a significant role in maintaining hemostatic balance in the body.

Thrombopoietin

9014-42-0: Thrombopoietin (TPO) is a glycoprotein hormone primarily produced by the liver and kidneys, playing a crucial role in the regulation of platelet production in the bone marrow. It functions by stimulating the proliferation and differentiation of megakaryocyte progenitor cells, which are responsible for producing platelets. TPO binds to the thrombopoietin receptor (MPL) on these progenitor cells, activating signaling pathways that promote cell survival and maturation. The substance is characterized by its relatively large molecular weight and complex glycosylation patterns, which are essential for its biological activity and stability. Thrombopoietin levels in the bloodstream are tightly regulated, with increased levels typically observed in response to low platelet counts. Dysregulation of TPO can lead to various hematological disorders, including thrombocytopenia and thrombocytosis. As a therapeutic agent, recombinant TPO or TPO mimetics are being explored for their potential in treating conditions associated with low platelet counts. Overall, TPO is a vital component of hematopoiesis and plays a significant role in maintaining hemostatic balance in the body.

<p>Thrombopoietin is a protein hormone that stimulates the production of platelets by the bone marrow. It is produced primarily by the liver and to a lesser degree in other tissues, including the brain, kidneys, and heart. Thrombopoietin activity can be inhibited by chemical inhibitors such as actinomycin D and cyclosporine A. This protein has been shown to play a role in immune responses and may be involved in many autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.</p>

CAS 9014-42-0

Thrombopoietin

Thrombopoietin from mouse

Ref: 3D-JAA01442