CAS 9015-85-4
:DNA ligase (ATP)
Description:
DNA ligase (ATP), with the CAS number 9015-85-4, is an enzyme that plays a crucial role in molecular biology, particularly in DNA replication and repair. This enzyme catalyzes the formation of phosphodiester bonds between adjacent nucleotides, effectively sealing nicks in the DNA backbone. DNA ligase requires adenosine triphosphate (ATP) as a cofactor, which provides the energy necessary for the ligation process. The enzyme is characterized by its specificity for double-stranded DNA and its ability to join fragments of DNA, such as Okazaki fragments during lagging strand synthesis. DNA ligase is essential for maintaining genomic integrity and is widely used in various biotechnological applications, including cloning, genetic engineering, and the construction of recombinant DNA molecules. Its activity can be influenced by factors such as temperature, pH, and the presence of other ions or molecules in the reaction environment. Overall, DNA ligase (ATP) is a vital tool in both natural biological processes and laboratory techniques.
Formula:Unspecified
Synonyms:- 9<sup>0</sup>N DNA Ligase
- 9<sup>0</sup>N ligase
- 9N DNA Ligase
- ATP-dependent DNA ligase
- CircLigase
- CircLigase I
- CircLigase II
- DNA joinase
- DNA ligase
- DNA ligase (ATP)
- DNA ligase 1
- DNA ligase I
- DNA-joining enzyme
- Deoxyribonucleate ligase
- Deoxyribonucleic acid joinase
- Deoxyribonucleic acid ligase
- Deoxyribonucleic joinase
- Deoxyribonucleic ligase
- Deoxyribonucleic-joining enzyme
- E.C. 6.5.1.1
- Ec 6.5.1.1
- NHR ligase
- Nucleotide ligase
- PBCV-1 ligase
- Pfu DNA Ligase
- Polydeoxyribonucleotide (adenosine triphosphate) synthetase
- Polynucleotide ligase
- Polynucleotide synthetase
- Polynucleotide synthetase (ATP)
- Sealase
- Single-stranded DNA cyclase
- Single-stranded DNA ligase
- Sintetasa, Polidesoxirribonucleotido
- SplintR ligase
- Synthetase, Polydeoxyribonucleotid
- Synthetase, Polydesoxyribonucleotide
- Synthetase, polydeoxyribonucleotide
- T3 DNA ligase
- T4 DNA ligase
- T4 polynucleotide ligase
- T7 DNA ligase
- Taq DNA ligase
- Thermophage DNA ligase
- See more synonyms
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DNA ligase (ATP)
CAS:<p>DNA ligase (ATP) is an enzyme (EC 6.5.1.1) that ligates DNA strands, repairing nicks in double-standed DNA and coupling blunt-ended or cohesive DNA fragments. It requires 3′ hydroxyl and 5′ phosphate nucleoside ends for ligation and ATP as a cofactor.</p>Molecular weight:0 g/mol
