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CAS 9016-12-0

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Hypoxanthine phosphoribosyltransferase

Description:
Hypoxanthine phosphoribosyltransferase (HPRT) is an enzyme that plays a crucial role in the purine salvage pathway, facilitating the conversion of hypoxanthine and phosphoribosyl pyrophosphate (PRPP) into inosine monophosphate (IMP). This enzyme is vital for nucleotide metabolism, allowing cells to recycle purines and maintain nucleotide pools, which are essential for DNA and RNA synthesis. HPRT is particularly important in tissues with high turnover rates, such as the brain and immune cells. Deficiency in HPRT can lead to Lesch-Nyhan syndrome, a genetic disorder characterized by neurological and behavioral abnormalities, as well as hyperuricemia. The enzyme is typically found in various organisms, including humans, and is encoded by the HPRT1 gene located on the X chromosome. Its activity can be influenced by various factors, including substrate availability and cellular conditions. The CAS number 9016-12-0 identifies this enzyme in chemical databases, facilitating research and study in biochemistry and pharmacology.
Formula:Unspecified
Synonyms:
  • HGPRT, IMP:pyrophosphate phosphoribosyltransferase, Transphosphoribosidase
  • E.C. 2.4.2.8
  • Guanine phosphoribosyltransferase
  • Hypoxanthine-guanine Phosphoribosyltransferase from baker's yeast (S.cerevisiae)
  • IMP:pyrophosphate phosphoribosyltransferase
  • Hypoxanthine-guanine phosphoribosyltransferase from Human, Recombinant
  • Phosphoribosyltransferase, hypoxanthine
  • Transphosphoribosidase
  • Inosinic pyrophosphorylase
  • HGPRT
  • Hypoxanthine phosphoribosyltransferase
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