Immunoproteasome activator 1, identified by its CAS number 901728-48-1, is a chemical compound that plays a significant role in the modulation of the immune response. It is known to enhance the activity of the immunoproteasome, a specialized form of the proteasome that is involved in the degradation of ubiquitinated proteins, particularly during immune responses. This compound is characterized by its ability to influence the processing of antigens and the presentation of peptides on major histocompatibility complex (MHC) molecules, thereby impacting T cell activation and the overall immune response. Immunoproteasome activator 1 is of interest in research related to autoimmune diseases, cancer immunotherapy, and infectious diseases, as it may help in the development of therapies that enhance immune function. Its mechanism of action typically involves the modulation of proteolytic activity and the alteration of cytokine production, contributing to a more effective immune surveillance. As with many chemical substances, safety and handling precautions should be observed when working with this compound in laboratory settings.

Immunoproteasome activator 1

901728-48-1: Immunoproteasome activator 1, identified by its CAS number 901728-48-1, is a chemical compound that plays a significant role in the modulation of the immune response. It is known to enhance the activity of the immunoproteasome, a specialized form of the proteasome that is involved in the degradation of ubiquitinated proteins, particularly during immune responses. This compound is characterized by its ability to influence the processing of antigens and the presentation of peptides on major histocompatibility complex (MHC) molecules, thereby impacting T cell activation and the overall immune response. Immunoproteasome activator 1 is of interest in research related to autoimmune diseases, cancer immunotherapy, and infectious diseases, as it may help in the development of therapies that enhance immune function. Its mechanism of action typically involves the modulation of proteolytic activity and the alteration of cytokine production, contributing to a more effective immune surveillance. As with many chemical substances, safety and handling precautions should be observed when working with this compound in laboratory settings.

Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.

CAS 901728-48-1

Immunoproteasome activator 1

Immunoproteasome activator 1

Ref: TM-T200985