α-Mannosidase is an enzyme that catalyzes the hydrolysis of α-mannosidic linkages in glycoproteins and oligosaccharides, playing a crucial role in the degradation of mannose-containing carbohydrates. It is classified as a glycoside hydrolase and is involved in various biological processes, including glycoprotein metabolism and cellular signaling. This enzyme is typically found in the lysosomes of eukaryotic cells and is essential for proper glycoprotein processing. Deficiencies in α-mannosidase can lead to lysosomal storage disorders, such as mannosidosis, which is characterized by the accumulation of mannose-rich oligosaccharides. α-Mannosidase is also utilized in biotechnology and research applications, particularly in the study of glycosylation patterns and the development of enzyme replacement therapies. The enzyme is generally stable under physiological conditions and exhibits optimal activity at specific pH and temperature ranges, which can vary depending on the source of the enzyme. Its activity can be influenced by various factors, including the presence of metal ions and inhibitors.

α-Mannosidase

9025-42-7: α-Mannosidase is an enzyme that catalyzes the hydrolysis of α-mannosidic linkages in glycoproteins and oligosaccharides, playing a crucial role in the degradation of mannose-containing carbohydrates. It is classified as a glycoside hydrolase and is involved in various biological processes, including glycoprotein metabolism and cellular signaling. This enzyme is typically found in the lysosomes of eukaryotic cells and is essential for proper glycoprotein processing. Deficiencies in α-mannosidase can lead to lysosomal storage disorders, such as mannosidosis, which is characterized by the accumulation of mannose-rich oligosaccharides. α-Mannosidase is also utilized in biotechnology and research applications, particularly in the study of glycosylation patterns and the development of enzyme replacement therapies. The enzyme is generally stable under physiological conditions and exhibits optimal activity at specific pH and temperature ranges, which can vary depending on the source of the enzyme. Its activity can be influenced by various factors, including the presence of metal ions and inhibitors.

<p>α-Mannosidase (α-D-mannopyranosidase, 1,2-α-mannosidase, 1,2-α-D-mannosidase, exo-α-mannosidase, α-D-mannosidase, systematic name α-D-mannoside mannohydrolase; EC 3.2.1.24) is an enzyme that cleaves α-mannose to produce glucose. One unit of α-Mannosidase will hydrolyze 1.0 µmole of chromogenic phosphate mimic p-nitrophenyl-α-p-mannoside to p-nitrophenol in 1 minute at pH 5.0 and 37°C.</p>

CAS 9025-42-7

α-Mannosidase

α-Mannosidase

Ref: 3D-JAA02542