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CAS 9028-48-2

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Isocitrate dehydrogenase (NADP)

Description:
Isocitrate dehydrogenase (NADP), with the CAS number 9028-48-2, is an enzyme that plays a crucial role in the citric acid cycle and the metabolic pathways of cellular respiration. This enzyme catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate, utilizing NADP+ as a cofactor, which is reduced to NADPH in the process. Isocitrate dehydrogenase (NADP) is primarily found in the mitochondria and is essential for the generation of NADPH, a key reducing agent in various biosynthetic reactions and in maintaining the cellular redox state. The enzyme is characterized by its dependence on divalent metal ions, such as magnesium or manganese, which are necessary for its activity. Additionally, it exhibits allosteric regulation, allowing it to respond to the metabolic needs of the cell. Mutations or deficiencies in this enzyme can lead to metabolic disorders, highlighting its importance in cellular metabolism and energy production.
Formula:NULL
Synonyms:
  • Dehydrogenase, Isocitrat (Nicotinamidadenindinucleotidphosphat)
  • Deshidrogenasa, Isocitrato (Nicotinamida Adenina Dinucleotido Fosfato)
  • Deshydrogenase, Isocitrate (Nicotinamide Adenine Dinucleotide Phosphate)
  • E.C. 1.1.1.42
  • Ec 1.1.1.42
  • Isocitrate (NADP) dehydrogenase
  • Isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase
  • Isocitrate dehydrogenase
  • Isocitrate dehydrogenase (NADP)
  • Isocitrate dehydrogenase (NADP-dependent)
  • See more synonyms
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