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CAS 9028-56-2

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3α-Hydroxysteroid dehydrogenase

Description:
3α-Hydroxysteroid dehydrogenase (3α-HSD) is an enzyme that plays a crucial role in the metabolism of steroid hormones, particularly in the conversion of 3α-hydroxysteroids to their corresponding ketones. This enzyme is involved in the regulation of various physiological processes, including the metabolism of androgens and estrogens. It is primarily found in the liver, brain, and other tissues, where it contributes to the biosynthesis and degradation of steroid hormones. The enzyme operates through a NAD(P)+-dependent mechanism, facilitating the oxidation-reduction reactions essential for steroid metabolism. Its activity can be influenced by various factors, including hormonal levels, substrate availability, and the presence of inhibitors or activators. Dysregulation of 3α-HSD activity has been implicated in several health conditions, including hormonal imbalances and certain endocrine disorders. Understanding the characteristics and functions of this enzyme is vital for exploring therapeutic targets in hormone-related diseases.
Formula:Unspecified
Synonyms:
  • EC 1.1.1.50
  • 3α-Hydroxysteroid dehydrogenase
  • 3α-Hydroxysteroid oxidoreductase
  • E.C. 1.1.1.50
  • Dehydrogenase, 3α-hydroxy steroid
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