CAS 9028-84-6
:Formaldehyde dehydrogenase
Description:
Formaldehyde dehydrogenase is an enzyme that plays a crucial role in the metabolism of formaldehyde, a toxic compound that can be produced endogenously or introduced through environmental exposure. This enzyme catalyzes the oxidation of formaldehyde to formate, utilizing NAD+ as a cofactor in the process. It is primarily found in various organisms, including bacteria and mammals, where it contributes to detoxification pathways. The enzyme exhibits specificity for formaldehyde and is essential for maintaining cellular homeostasis by preventing the accumulation of this reactive aldehyde. Formaldehyde dehydrogenase is characterized by its dependence on cofactors, its role in metabolic pathways, and its potential implications in bioremediation and industrial applications. Additionally, the enzyme's activity can be influenced by factors such as pH, temperature, and the presence of inhibitors or activators. Understanding the characteristics and functions of formaldehyde dehydrogenase is important for both environmental health and therapeutic applications, particularly in contexts where formaldehyde exposure is a concern.
Formula:Unspecified
Synonyms:- Dehydrogenase, formaldehyde
- E.C. 1.2.1.1
- E.C. 1.2.1.46
- Ec 1.2.1.1
- Ec 1.2.1.46
- Formaldehyde Dehydrogenase from Pseudomonas putida
- Formaldehyde dehydrogenase
- Formaldehyde dehydrogenase (NAD)
- Formaldehyde dehydrogenases
- Glutathione dependent formaldehyde dehydrogenases
- Glutathione-dependent formaldehyde dehydrogenase
- NAD-linked formaldehyde dehydrogenase
- NAD-linked formaldehyde dehydrogenases
- NADH-dependent GSNO reductase
- NADH-dependent GSNO reductases
- NADH-dependent S-nitrosoglutathione reductase
- NADH-dependent S-nitrosoglutathione reductases
- S-Nitrosoglutathione reductase
- See more synonyms
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Formaldehyde Dehydrogenase
CAS:Formaldehyde dehydrogenase (EC 1.2.1.46) is an enzyme that catalyzes the following reaction: formaldehyde + NAD+ + H2O ⇌ formate + NADH + H+ One unit of formaldehyde dehydrogenase will convert 1.0 µmole of formaldehyde to formic acid per minute at pH 7.5 and 37°C in the presence of NAD+.NAD+ is available here.
