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CAS 9029-12-3

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Glutamate dehydrogenase (NAD(P))

Description:
Glutamate dehydrogenase (NAD(P)) is an enzyme that plays a crucial role in amino acid metabolism, specifically in the oxidative deamination of glutamate to α-ketoglutarate, utilizing NAD+ or NADP+ as a cofactor. This enzyme is vital for the regulation of nitrogen metabolism and energy production in cells. It is found in various organisms, including bacteria, plants, and animals, and is particularly significant in the liver and brain. The enzyme operates in both directions, facilitating the conversion of α-ketoglutarate back to glutamate in the presence of ammonia, which is essential for amino acid synthesis and the urea cycle. Glutamate dehydrogenase is characterized by its sensitivity to allosteric regulation, being influenced by various metabolites and energy status of the cell. Its activity can be modulated by factors such as pH, temperature, and the concentration of substrates and products. The CAS number 9029-12-3 identifies this enzyme in chemical databases, aiding in research and application in biochemistry and biotechnology.
Formula:Unspecified
Synonyms:
  • Dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))
  • Glutamate dehydrogenase (NAD(P))
  • E.C. 1.4.1.3
  • Glutamate dehydrogenase (nicotinamide adenine dinucleotide (phosphate))
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