CAS 9030-21-1

Purine nucleoside phosphorylase

Description:

Purine nucleoside phosphorylase (PNP) is an enzyme that plays a crucial role in the purine salvage pathway, facilitating the reversible phosphorolysis of purine nucleosides into their corresponding bases and ribose-1-phosphate. This enzyme is essential for nucleotide metabolism, particularly in the recycling of purines, which are vital for DNA and RNA synthesis. PNP is a homotrimeric protein, meaning it consists of three identical subunits, and it exhibits a preference for specific nucleosides, such as inosine and guanosine. The enzyme's activity is regulated by various factors, including substrate concentration and the presence of inhibitors. Deficiencies in PNP can lead to severe immunodeficiency disorders, highlighting its importance in cellular metabolism and immune function. The CAS number 9030-21-1 identifies this enzyme in chemical databases, facilitating research and applications in biochemistry and pharmacology. Overall, PNP is a key enzyme in purine metabolism, with significant implications for health and disease.

Formula: NULL

Synonyms:

• Deoxyribonucleoside phosphorylase
• E.C. 2.4.2.1
• Fosforilasa, Purina Nucleosido
• Inosine phosphorylase
• Inosine-guanosine phosphorylase
• Nucleotide phosphatase (2.4.2.1)
• Phosphorylase, Purin-, Nucleosid
• Purine deoxynucleoside phosphorylase
• Purine deoxyribonucleoside phosphorylase
• Purine nucleoside phosphorylase
• Purine ribonucleoside phosphorylase
• Phosphorylase, purine nucleoside
• NUCLEOSIDE PHOSPHORYLASE
• Purine Nucleoside Phosphorylase, ≥200U/mg protein
• NUCLEOSIDE PHOSPHORYLASE FROM HUMAN*BLOO D
• PURINE NUCLEOSIDE: ORTHOPHOSPHATE RIBOSYLTRANSFERASE
• Recombinant mutant (Met62Val) purine nucleoside phosphorylase from E. coli
• PNP/Purine-nucleoside phosphorylase
• Nucleoside Phosphorylase from bacterial, Recombinant
• Purine nucleoside phosphorylase, Recombinant
• Nucleoside Phosphorylase bacterial,PNP, Purine nucleoside phosphorylase, Purine nucleoside:orthophosphate ribosyltransferase
• PNP
• Native Microorganisms Nucleoside Phosphorylase
• Purine nucleoside phosphorylase, Purine nucleoside:orthophosphate ribosyltransferase
• Purine-nucleoside phosp
• Native Bacillus sp. Purine Nucleoside Phosphorylase
• Purine nucleoside phosphorylase [ >=200 units/mg]
• EC 2.4.2.1
• C:C&B24
• NUCLEOSIDE PHOSPHORYLASE USP/EP/BP
• Nucleoside Phosphorylase from microorganisms

Nucleoside Phosphorylase

CAS: 9030-21-1

Ref: 7W-GZ4655

Purine nucleoside phosphorylase

CAS: 9030-21-1

Purine nucleoside phosphorylase deficiency impairs T cells; it breaks bonds in DNA components, releasing bases and ribose phosphate.

Color and Shape: Solid

Ref: TM-T76096

Nucleoside phosphorylase from microorganisms

CAS: 9030-21-1

Nucleoside phosphorylase (Purine nucleoside phosphorylase, PNP, PNPase, inosine phosphorylase, inosine-guanosine phosphorylase; EC 2.4.2.1) is an enzyme that catalyzes the following reaction:  purine nucleoside + Pi ⇌ purine + alpha-D-ribose 1-phosphate  One unit of nucleoside phosphorylase will phosphorylate 1.0 micromole of inosine to hypoxanthine and alpha-D-ribose 1-phosphate per min at pH 7.4 and 25°C.

Formula: C₅H₆ClN₃

Purity: Min. 95%

Molecular weight: 143.57 g/mol

Ref: 3D-JAA03021