CAS 90301-60-3

2'-deoxy-5-(2-hydroxyethyl)uridine

Description:

2'-Deoxy-5-(2-hydroxyethyl)uridine is a nucleoside analog that features a uridine base modified with a 2-hydroxyethyl group at the 5-position of the pyrimidine ring. This compound is characterized by its structural similarity to natural nucleosides, which allows it to participate in biochemical processes, particularly in nucleic acid synthesis. The presence of the 2-hydroxyethyl group enhances its solubility and may influence its biological activity, potentially affecting interactions with nucleic acid polymerases. As a derivative of uridine, it retains the essential ribose sugar structure, but the modification can alter its pharmacokinetic properties and stability. This compound is of interest in medicinal chemistry and biochemistry, particularly in the development of antiviral agents and as a tool in molecular biology research. Its CAS number, 90301-60-3, is a unique identifier that facilitates the tracking and study of this specific chemical substance in scientific literature and databases.

Formula: C₁₁H₁₆N₂O₆

InChI: InChI=1/C11H16N2O6/c14-2-1-6-4-13(11(18)12-10(6)17)9-3-7(16)8(5-15)19-9/h4,7-9,14-16H,1-3,5H2,(H,12,17,18)/t7-,8+,9+/m0/s1

Synonyms:

• 5-(2-HYDROXYETHYL)-2'-DEOXYURIDINE
• 5-(2-Hyroxyethyl)-2’-deoxyuridine
• 2'-Deoxy-5-(2-hydroxyethyl)uridine
• Uridine, 2'-deoxy-5-(2-hydroxyethyl)-
• 5-Hydroxyethyl-2'-Deoxyuridine
• 5-(2-Hyroxyethyl)-2'-deoxyuridine

5-(2-Hydroxyethyl)-2''-deoxyuridine

CAS: 90301-60-3

Ref: 7W-GC7906

5-(2-Hyroxyethyl)-2'-deoxyuridine

CAS: 90301-60-3

5-(2-Hyroxyethyl)-2'-deoxyuridine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside.

Formula: C₁₁H₁₆N₂O₆

Color and Shape: Solid

Molecular weight: 272.25

Ref: TM-TNU1280

5-(2-Hydroxyethyl)-2'-deoxyuridine

CAS: 90301-60-3

5-(2-Hydroxyethyl)-2'-deoxyuridine is a regiospecific inhibitor of the enzyme thymidylate synthase. This drug inhibits the synthesis of thymine and uracil, which are used in DNA replication. 5-(2-Hydroxyethyl)-2'-deoxyuridine binds to the carbon chain of uracil, preventing its incorporation into DNA. 5-(2-Hydroxyethyl)-2'-deoxyuridine has been shown to be an effective inhibitor of thymidylate synthase in both prokaryotic and eukaryotic cells. The mechanism of action is thought to be competitive inhibition with respect to substrate binding at the active site of the enzyme. 5-(2-Hydroxyethyl)-2'-deoxyuridine can be synthesized by reacting acrylonitrile with 5-iodouridine chloride, followed by elimination reactions with methylene chloride or thionyl chloride. The product can then be

Formula: C₁₁H₁₆N₂O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 272.25 g/mol

Ref: 3D-MH16752