Ceruloplasmin is a copper-carrying protein found in the blood, primarily synthesized in the liver. It plays a crucial role in iron metabolism and is involved in the oxidation of ferrous iron (Fe²⁺) to ferric iron (Fe³⁺), facilitating iron transport and storage. This protein is characterized by its blue color, which is attributed to the presence of copper ions. Ceruloplasmin has a molecular weight of approximately 151 kDa and consists of multiple copper-binding sites, allowing it to transport copper in a biologically active form. It also exhibits antioxidant properties, helping to neutralize free radicals in the body. Deficiencies or abnormalities in ceruloplasmin levels can be associated with various health conditions, including Wilson's disease, Menkes disease, and certain types of anemia. Its measurement in serum is often used as a diagnostic tool to assess copper metabolism and related disorders. Overall, ceruloplasmin is essential for maintaining copper homeostasis and plays a significant role in various physiological processes.

Ceruloplasmin

9031-37-2: Ceruloplasmin is a copper-carrying protein found in the blood, primarily synthesized in the liver. It plays a crucial role in iron metabolism and is involved in the oxidation of ferrous iron (Fe²⁺) to ferric iron (Fe³⁺), facilitating iron transport and storage. This protein is characterized by its blue color, which is attributed to the presence of copper ions. Ceruloplasmin has a molecular weight of approximately 151 kDa and consists of multiple copper-binding sites, allowing it to transport copper in a biologically active form. It also exhibits antioxidant properties, helping to neutralize free radicals in the body. Deficiencies or abnormalities in ceruloplasmin levels can be associated with various health conditions, including Wilson's disease, Menkes disease, and certain types of anemia. Its measurement in serum is often used as a diagnostic tool to assess copper metabolism and related disorders. Overall, ceruloplasmin is essential for maintaining copper homeostasis and plays a significant role in various physiological processes.

<p>Ceruloplasmin is a ferroxidase that is found in the human body. It plays an important role in iron homeostasis and has been shown to be involved in the molecular pathogenesis of diabetes mellitus type 2. Ceruloplasmin also has a protective effect on probiotic bacteria and has been shown to inhibit bacterial growth. Ceruloplasmin binds to bacterioferritin, which can reduce the toxicity of nitric oxide radicals. The protein's biological properties have been studied using x-ray crystal structures and titration calorimetry methods. Ceruloplasmin is found at physiological levels in human serum, but may not be detectable in people with hepatic steatosis or other liver diseases.</p>

CAS 9031-37-2

Ceruloplasmin

Ceruloplasmin human

Ref: 3D-JAA03137