B-nad synthetase, also known as NAD synthetase, is an enzyme that plays a crucial role in the biosynthesis of nicotinamide adenine dinucleotide (NAD), an essential coenzyme involved in various metabolic processes. This enzyme catalyzes the conversion of nicotinamide mononucleotide (NMN) to NAD, utilizing ATP in the process. B-nad synthetase is characterized by its specificity for substrates and its dependence on divalent metal ions, such as magnesium or manganese, which are often required for its activity. The enzyme is typically found in various organisms, including bacteria and eukaryotes, and is vital for cellular respiration and energy production. Its activity is tightly regulated, reflecting the cellular demand for NAD, which is crucial for redox reactions and as a substrate for NAD-dependent enzymes. The CAS number 9032-69-3 identifies this enzyme in chemical databases, facilitating research and application in biochemistry and biotechnology. Understanding the characteristics and function of B-nad synthetase is important for exploring metabolic pathways and potential therapeutic targets in various diseases.

B-nad synthetase

9032-69-3: B-nad synthetase, also known as NAD synthetase, is an enzyme that plays a crucial role in the biosynthesis of nicotinamide adenine dinucleotide (NAD), an essential coenzyme involved in various metabolic processes. This enzyme catalyzes the conversion of nicotinamide mononucleotide (NMN) to NAD, utilizing ATP in the process. B-nad synthetase is characterized by its specificity for substrates and its dependence on divalent metal ions, such as magnesium or manganese, which are often required for its activity. The enzyme is typically found in various organisms, including bacteria and eukaryotes, and is vital for cellular respiration and energy production. Its activity is tightly regulated, reflecting the cellular demand for NAD, which is crucial for redox reactions and as a substrate for NAD-dependent enzymes. The CAS number 9032-69-3 identifies this enzyme in chemical databases, facilitating research and application in biochemistry and biotechnology. Understanding the characteristics and function of B-nad synthetase is important for exploring metabolic pathways and potential therapeutic targets in various diseases.

<p>NAD Synthetase is responsible for the final step in the synthesis of Nicotinamide Adenine Dinucleotide (NAD). The enzyme sourced from Escherichia coli exhibits Km values of 200 μM for NAD, 11 μM for ATP, and 0.65 μM for ammonia. Conversely, NAD Synthetase derived from yeast demonstrates Km values of 170 μM for NAD, 190 μM for ATP, and 64 μM for ammonia. This enzyme is applicable in enzymatic assays for ATP, ammonia, urea, or creatinine and can also be used in enzymatic recycling methods. Additionally, NAD Synthetase holds potential for research into metabolic diseases, cancer, aging, and neurodegenerative disorders.</p>

CAS 9032-69-3

B-nad synthetase

NAD Synthetase

Ref: TM-T200236