Sortase A from Staphylococcus aureus is an enzyme that plays a critical role in the anchoring of surface proteins to the bacterial cell wall. It is a cysteine transpeptidase that recognizes specific sorting signals in substrate proteins, facilitating the covalent attachment of these proteins to the peptidoglycan layer of the bacterial cell wall. This process is essential for the virulence of S. aureus, as it allows the bacteria to display surface proteins that contribute to adhesion, immune evasion, and biofilm formation. Sortase A operates through a mechanism that involves the cleavage of a peptide bond and the formation of a thioester intermediate, which subsequently reacts with the cell wall. The enzyme is of significant interest in biotechnology and medicine, particularly for its potential applications in vaccine development and the creation of novel protein conjugates. Its CAS number, 9033-39-0, identifies it in chemical databases, facilitating research and development efforts related to this important bacterial enzyme.

Sortase A, S. aureus

9033-39-0: Sortase A from Staphylococcus aureus is an enzyme that plays a critical role in the anchoring of surface proteins to the bacterial cell wall. It is a cysteine transpeptidase that recognizes specific sorting signals in substrate proteins, facilitating the covalent attachment of these proteins to the peptidoglycan layer of the bacterial cell wall. This process is essential for the virulence of S. aureus, as it allows the bacteria to display surface proteins that contribute to adhesion, immune evasion, and biofilm formation. Sortase A operates through a mechanism that involves the cleavage of a peptide bond and the formation of a thioester intermediate, which subsequently reacts with the cell wall. The enzyme is of significant interest in biotechnology and medicine, particularly for its potential applications in vaccine development and the creation of novel protein conjugates. Its CAS number, 9033-39-0, identifies it in chemical databases, facilitating research and development efforts related to this important bacterial enzyme.

<p>Sortase A, S. aureus (SrtA) is found in many Gram-positive bacteria and facilitates the recruitment of cell surface proteins. It plays a crucial role in the attachment of various molecules on the cell surface.</p>

CAS 9033-39-0

Sortase A, S. aureus

Sortase A, S. aureus

Ref: TM-TRP-00383