CAS 90331-82-1

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH

Description:

The chemical substance known as H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH, with the CAS number 90331-82-1, is a synthetic peptide that consists of a sequence of amino acids. This peptide features a combination of both standard and modified amino acids, including proline (Pro), threonine (Thr), glutamic acid (Glu), phenylalanine (Phe), p-nitrophenylalanine (p-nitro-Phe), arginine (Arg), and leucine (Leu). The presence of p-nitrophenylalanine indicates that this peptide may have unique optical or electronic properties, making it of interest in various biochemical applications. Peptides like this one are often studied for their roles in biological processes, potential therapeutic applications, and as tools in drug design. The C-terminal amide (OH) suggests that it may exhibit enhanced stability and bioactivity. Overall, this peptide's characteristics, including its sequence and modifications, contribute to its potential utility in research and pharmaceutical development.

Formula: C₄₄H₆₃N₁₁O₁₃

InChI: InChI=1/C44H63N11O13/c1-24(2)21-34(43(65)66)53-38(60)30(12-8-20-48-44(45)46)49-40(62)33(23-27-13-15-28(16-14-27)55(67)68)52-41(63)32(22-26-9-5-4-6-10-26)51-39(61)31(17-18-35(57)58)50-42(64)36(25(3)56)54-37(59)29-11-7-19-47-29/h4-6,9-10,13-16,24-25,29-34,36,47,56H,7-8,11-12,17-23H2,1-3H3,(H,49,62)(H,50,64)(H,51,61)(H,52,63)(H,53,60)(H,54,59)(H,57,58)(H,65,66)(H4,45,46,48)/t25-,29+,30+,31+,32+,33+,34+,36+/m1/s1

Synonyms:

• Prolyl-threonyl-glutamyl-phenylalanyl-4-nitrophenylalanyl-arginyl-leucine
• Pro-thr-glu-phe-4-nitro-phe-arg-leu
• Ptgp-NP-AL
• L-Leucine, N-(N2-(4-nitro-N-(N-(N-(N-L-prolyl-L-threonyl)-L-alpha-glutamyl)-L-phenylalanyl)-L-phenylalanyl)-L-arginyl)-, (2'E)-
• L-prolyl-L-threonyl-L-alpha-glutamyl-L-phenylalanyl-4-nitro-L-phenylalanyl-N~5~-(diaminomethylidene)-L-ornithyl-L-leucine

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH

CAS: 90331-82-1

The p-nitrophenylalanine-containing substrate PTEF-Nph-RL has been developed for a convenient assay of pepsin and other aspartic proteinases of animal and microbial origin. It is soluble over a wide pH range, with the Km values showing only little variation (Km = 80 µM at pH 3.1 and 37°C for porcine pepsin).

Formula: C₄₄H₆₃N₁₁O₁₃

Purity: 99.4%

Color and Shape: White Powder

Molecular weight: 954.05

Ref: 01-4031188

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH

CAS: 90331-82-1

H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a proteolytic inhibitor that inhibits the aspartic and hydrolytic enzymes. It has been shown to inhibit the activity of trypsin, pepsin, and elastase in human serum. This inhibitor also inactivates fibronectin by proteolysis. H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu OH has been shown to be specific for acidic proteases such as pepsin. The natural inhibitors of this peptide are Pro, Thr, Glu, Phe, Arg and Leu.

Formula: C₄₄H₆₃N₁₁O₁₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 954.04 g/mol

Ref: 3D-FP108337