CAS 90357-06-5
:Bicalutamide
Description:
Bicalutamide is a non-steroidal anti-androgen medication primarily used in the treatment of prostate cancer. It functions by selectively inhibiting the action of androgens, such as testosterone, at the androgen receptor level, thereby slowing the growth of hormone-sensitive tumors. The chemical formula of bicalutamide is C18H14F4N2O2S, and it features a complex structure that includes a thiourea moiety and a fluorinated aromatic ring. Bicalutamide is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. Common side effects may include hot flashes, gastrointestinal disturbances, and potential liver function alterations. It is important to monitor patients for these effects during treatment. Bicalutamide is often used in combination with other therapies, such as luteinizing hormone-releasing hormone (LHRH) agonists, to enhance its efficacy in managing advanced prostate cancer. As with any medication, its use should be guided by a healthcare professional, considering the individual patient's condition and treatment goals.
Formula:C18H14F4N2O4S
InChI:InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChI key:InChIKey=LKJPYSCBVHEWIU-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C1=C(C#N)C=CC(NC(C(CS(=O)(=O)C2=CC=C(F)C=C2)(C)O)=O)=C1
Synonyms:- (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
- (±)-4′-Cyano-α,α,α-trifluoro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide
- 4-cyano-3-trifluoromethyl-N-(3-p-fluorophenylsulfonyl-2-hydroxy-2-methylpropionyl)aniline
- Bicalutamide (Subject to patent free)
- Casode
- Casodex
- Cosudex
- Ici 176334
- N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methyl-propanamid
- N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
- Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-
- Zd 176334
- See more synonyms
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Found 20 products.
Bicalutamide
CAS:Formula:C18H14F4N2O4SPurity:>98.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:430.37Bicalutamide
CAS:BicalutamideFormula:C18H14F4N2O4SPurity:99.7%Color and Shape:WhiteMolecular weight:430.06104Bicalutamide
CAS:Other aromatic organo-sulfur compounds (excluding pesticides)Formula:C18H14F4N2O4SColor and Shape:White Off-White PowderMolecular weight:430.06104Bicalutamide
CAS:<p>Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the</p>Formula:C18H14F4N2O4SPurity:98% - 99.87%Color and Shape:Off-White Crystalline SolidMolecular weight:430.37Bicalutamide
CAS:Formula:C18H14F4N2O4SColor and Shape:White To Off-White SolidMolecular weight:430.37Bicalutamide
CAS:Formula:C18H14F4N2O4SPurity:≥ 98.0% (dried basis)Color and Shape:White or almost white powderMolecular weight:430.37Bicalutamide
CAS:Controlled Product<p>Applications Non-steroidal peripherally active antiandrogen. Used as an antiandrogen, antineoplastic (hormonal); Non-steroidal androgen receptor antagonist that binds the androgen receptor and prevents its activation.<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>Formula:C18H14F4N2O4SColor and Shape:WhiteMolecular weight:430.37Bicalutamide
CAS:<p>Androgen receptor antagonist</p>Formula:C18H14F4N2O4SPurity:Min. 97 Area-%Color and Shape:White PowderMolecular weight:430.37 g/molBicalutamide Crystalline Form II
CAS:Controlled ProductFormula:C18H14F4N2O4SColor and Shape:NeatMolecular weight:430.37
