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CAS 90357-06-5

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Bicalutamide

Description:
Bicalutamide is a non-steroidal anti-androgen medication primarily used in the treatment of prostate cancer. It functions by selectively inhibiting the action of androgens, such as testosterone, at the androgen receptor level, thereby slowing the growth of hormone-sensitive tumors. The chemical formula of bicalutamide is C18H14F4N2O2S, and it features a complex structure that includes a thiourea moiety and a fluorinated aromatic ring. Bicalutamide is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. Common side effects may include hot flashes, gastrointestinal disturbances, and potential liver function alterations. It is important to monitor patients for these effects during treatment. Bicalutamide is often used in combination with other therapies, such as luteinizing hormone-releasing hormone (LHRH) agonists, to enhance its efficacy in managing advanced prostate cancer. As with any medication, its use should be guided by a healthcare professional, considering the individual patient's condition and treatment goals.
Formula:C18H14F4N2O4S
InChI:InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChI key:InChIKey=LKJPYSCBVHEWIU-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C1=C(C#N)C=CC(NC(C(CS(=O)(=O)C2=CC=C(F)C=C2)(C)O)=O)=C1
Synonyms:
  • (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
  • (±)-4′-Cyano-α,α,α-trifluoro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide
  • 4-cyano-3-trifluoromethyl-N-(3-p-fluorophenylsulfonyl-2-hydroxy-2-methylpropionyl)aniline
  • Bicalutamide (Subject to patent free)
  • Casode
  • Casodex
  • Cosudex
  • Ici 176334
  • N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methyl-propanamid
  • N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
  • See more synonyms
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