CAS 903576-44-3

pitolisant hydrochloride

Description:

Pitolisant hydrochloride is a medication primarily used for the treatment of narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and cataplexy. It functions as a selective histamine H3 receptor antagonist/inverse agonist, which enhances the release of histamine and promotes wakefulness. The substance is typically administered in its hydrochloride salt form, which improves its solubility and stability. Pitolisant has a favorable pharmacokinetic profile, with a relatively long half-life, allowing for once-daily dosing. It is generally well-tolerated, though potential side effects may include insomnia, anxiety, and gastrointestinal disturbances. The chemical structure of pitolisant includes a piperidine ring, contributing to its pharmacological activity. As a novel treatment option, it represents a significant advancement in the management of narcolepsy, providing an alternative to traditional stimulant medications. Its development underscores the importance of targeting specific neurotransmitter systems to improve wakefulness and overall quality of life for individuals affected by sleep disorders.

Synonyms:

• Ciproxidine
• Bf2649

Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-, hydrochloride

CAS: 903576-44-3

Formula: C₁₇H₂₇Cl₂NO

Purity: 97%

Color and Shape: Solid

Molecular weight: 332.3084

Ref: IN-DA006FBP

Pitolisant HCl

CAS: 903576-44-3

Formula: C₁₇H₂₆ClNO·HCl

Molecular weight: 295.85 36.46

Ref: 4Z-P-401001

Pitolisant hydrochloride

CAS: 903576-44-3

Pitolisant hydrochloride

Purity: ≥98%

Molecular weight: 332.31g/mol

Ref: 54-BUP15507

Pitolisant hydrochloride

CAS: 903576-44-3

Pitolisant hydrochloride (Ciproxidine) is a potent and selective inverse agonist of the histamine H3 receptor(Ki : 0.16 nM).

Formula: C₁₇H₂₇Cl₂NO

Purity: 99.72% - 99.91%

Color and Shape: Solid

Molecular weight: 332.31

Ref: TM-T7176

Pitolisant Hydrochloride

CAS: 903576-44-3

Formula: C₁₇H₂₆ClNO•HCl

Color and Shape: Neat

Ref: TR-B360003

Pitolisant hydrochloride

CAS: 903576-44-3

Pitolisant is an inverse agonist and antagonist of the histamine (H3) receptor. It acts as an allosteric modulator of the H3 receptor to increase the activity of histamine at the M1 receptor. Pitolisant has been used in the treatment of narcolepsy, schizophrenia and Alzheimer's disease. Its mechanism of action involves binding to the amide group on histamine, which increases its affinity for the H3 receptor and enhances its activity at this site. Pitolisant has been shown to improve cognitive ability and reduce fatigue in patients with Alzheimer's disease.

Formula: C₁₇H₂₆ClNO·HCl

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 332.31 g/mol

Ref: 3D-FC153335

Pitolisant hydrochloride - Bio-X ™

CAS: 903576-44-3

Pitolisant is an inverse agonist and antagonist of the histamine (H3) receptor. It acts as an allosteric modulator of the H3 receptor to increase the activity of histamine at the M1 receptor. Pitolisant has been used in the treatment of narcolepsy, schizophrenia and Alzheimer's disease. Its mechanism of action involves binding to the amide group on histamine, which increases its affinity for the H3 receptor and enhances its activity at this site. Pitolisant has been shown to improve cognitive ability and reduce fatigue in patients with Alzheimer's disease.
Pitolisant is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₇H₂₆ClNO·HCl

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 332.31 g/mol

Ref: 3D-FB35077