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CAS 9039-53-6

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Urokinase (peptidolytic)

Description:
Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease enzyme that plays a crucial role in the fibrinolytic system, facilitating the breakdown of fibrin in blood clots. It is produced primarily by the kidneys and is involved in various physiological processes, including tissue remodeling and wound healing. Urokinase acts by converting plasminogen into plasmin, the active enzyme responsible for fibrinolysis. The enzyme is characterized by its ability to cleave peptide bonds, which is essential for its function in promoting the dissolution of blood clots. Urokinase is utilized therapeutically in the treatment of conditions such as pulmonary embolism and myocardial infarction, where rapid clot dissolution is necessary. Its use is regulated due to potential side effects, including bleeding complications. The CAS number 9039-53-6 identifies this specific enzyme, which is often derived from human urine or produced through recombinant DNA technology for clinical applications. Overall, urokinase is a vital component in both normal physiological processes and medical treatments related to thrombotic disorders.
Formula:Unspecified
Synonyms:
  • 2-Chain urokinase
  • Abbokinase
  • Actosolv
  • Breokinase
  • Cytokinase
  • Double-chain urokinase-type plasminogen activator
  • E.C. 3.4.21.31
  • E.C. 3.4.21.73
  • E.C. 3.4.99.26
  • Kinase (Activatrice D'Enzyme), Uro-
  • See more synonyms
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