CAS 9041-92-3
:α1-Antitrypsin
Description:
α1-Antitrypsin (AAT) is a glycoprotein primarily produced in the liver, functioning as a serine protease inhibitor (serpin) that protects tissues from enzymes of inflammatory cells, particularly neutrophil elastase. It plays a crucial role in regulating the immune response and maintaining tissue integrity. The CAS number 9041-92-3 identifies a specific form of this protein, which is important in clinical contexts, particularly in the diagnosis and treatment of conditions such as emphysema and liver disease associated with AAT deficiency. This protein exhibits a molecular weight of approximately 52 kDa and is characterized by its ability to inhibit various proteolytic enzymes, thus preventing excessive tissue damage during inflammation. AAT levels can be influenced by genetic factors, liver function, and inflammatory states, making it a significant biomarker in various diseases. Additionally, AAT can be administered therapeutically in individuals with deficiency to mitigate the risk of lung and liver damage. Its structure includes a reactive center loop that is critical for its inhibitory function, and it exists in multiple allelic forms, which can affect its activity and stability.
Formula:Unspecified
Synonyms:- A1Pi
- Alpha-1-Proteinase Inhibitor (Human)
- Alpha-1-proteinase inhibitor
- Antitrypsin Pittsburgh
- Aralast
- Aralast NP
- Glassia
- Human Alpha1- PI
- Inhibidor De Tripsina, Α1-
- Prolastin
- Prolastin C
- Respitin
- Serpin A 1
- Serpin A1
- Serpin, clade A
- Serpina1
- Serpina2
- Trypsin Inhibitor, alpha 1-Antitrypsin
- Trypsin inhibitor, alpha1-
- Trypsin inhibitor, α<sub>1</sub>-
- Trypsin-inhibiting protein Serpin A1
- Trypsine, Α1-, Inhibiteur
- Unii-F43I396Ois
- Zemaira
- alpha 1-Antitrypsin
- alpha-1-Protease inhibitor
- alpha1-Antiprotease
- alpha1-Antiproteinase
- alpha1-Antitrypsin
- alpha1-Antitrypsin Pittsburgh mutant
- alpha1-Antitrypsin Portland
- alpha1-Proteinase inhibitor
- alpha1-Trypsin inhibitor
- α 1-PDX
- α-1-Protease inhibitor
- α1-AT
- α1-Antiprotease
- α1-Antiproteinase
- α1-Antitrypsin
- α1-Antitrypsin Pittsburgh mutant
- α1-Antitrypsin Portland
- α1-Protease inhibitor
- α1-Proteinase inhibitor
- α1-Trypsin inhibitor
- α<sub>1</sub>-Antiproteinase
- α<sub>1</sub>-Antitrypsin Pittsburgh mutant
- α<sub>1</sub>-Antitrypsin Portland
- α<sub>1</sub>-Protease inhibitor
- α<sub>1</sub>-Proteinase inhibitor
- α<sub>1</sub>-Trypsin inhibitor
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