Microsomal aminopeptidase, with the CAS number 9054-63-1, is an enzyme that plays a crucial role in protein metabolism by catalyzing the removal of amino acids from the N-terminus of peptides and proteins. This enzyme is primarily located in the endoplasmic reticulum of cells, particularly in the liver and other tissues involved in protein processing. It exhibits broad substrate specificity, allowing it to act on various peptide sequences, which is essential for the regulation of peptide levels and the generation of bioactive peptides. Microsomal aminopeptidase is a membrane-bound enzyme, which means it is associated with cellular membranes, and its activity can be influenced by factors such as pH and the presence of metal ions. Additionally, it is involved in the degradation of misfolded proteins, contributing to cellular quality control mechanisms. Understanding the characteristics and functions of microsomal aminopeptidase is important for insights into metabolic pathways and potential therapeutic targets in diseases related to protein misfolding and degradation.

Microsomal aminopeptidase

9054-63-1: Microsomal aminopeptidase, with the CAS number 9054-63-1, is an enzyme that plays a crucial role in protein metabolism by catalyzing the removal of amino acids from the N-terminus of peptides and proteins. This enzyme is primarily located in the endoplasmic reticulum of cells, particularly in the liver and other tissues involved in protein processing. It exhibits broad substrate specificity, allowing it to act on various peptide sequences, which is essential for the regulation of peptide levels and the generation of bioactive peptides. Microsomal aminopeptidase is a membrane-bound enzyme, which means it is associated with cellular membranes, and its activity can be influenced by factors such as pH and the presence of metal ions. Additionally, it is involved in the degradation of misfolded proteins, contributing to cellular quality control mechanisms. Understanding the characteristics and functions of microsomal aminopeptidase is important for insights into metabolic pathways and potential therapeutic targets in diseases related to protein misfolding and degradation.

Aminopeptidase M (AMP) inhibition is of interest for several diseases, such as highly vascularized cancer types.

Aminopeptidase M

<p>Leucine aminopeptidase (L-leucine aminopeptidase, Leucyl aminopeptidase, leucyl peptidase, peptidase S; EC 3.4.11.1) is an exopeptidase enzyme. It preferentially catalyses the removal of N-terminal leucine residues from proteins and peptides.</p>

CAS 9054-63-1

Microsomal aminopeptidase

Aminopeptidase M

Ref: TM-T9345

Leucine aminopeptidase, microsomal from porcine kidney

Ref: 3D-JAA05463