CAS 9060-10-0

Bleomycin B2

Description:

Bleomycin B2 is a glycopeptide antibiotic derived from the bacterium Streptomyces verticillus. It is part of the bleomycin family, which is known for its antitumor properties, particularly in the treatment of various cancers, including testicular cancer and Hodgkin's lymphoma. The compound exhibits a unique mechanism of action by inducing DNA strand breaks through the formation of free radicals, which ultimately leads to cell death. Bleomycin B2 is characterized by its complex structure, which includes a DNA-binding domain and an iron-binding moiety that facilitates its interaction with DNA. It is typically administered via injection and can cause side effects such as pulmonary toxicity and skin reactions. The compound is notable for its ability to selectively target rapidly dividing cells, making it effective in cancer therapy. However, its use is carefully monitored due to potential adverse effects, particularly in patients with pre-existing lung conditions. Overall, Bleomycin B2 represents a significant tool in oncological pharmacotherapy, with ongoing research into its mechanisms and applications.

Formula: C₅₅H₈₄N₂₀O₂₁S₂

InChI: InChI=1S/C55H84N20O21S2/c1-19-32(72-45(75-43(19)58)24(11-30(57)79)67-12-23(56)44(59)85)49(89)74-34(40(25-13-63-18-68-25)94-53-42(38(83)36(81)28(14-76)93-53)95-52-39(84)41(96-55(62)91)37(82)29(15-77)92-52)50(90)69-21(3)35(80)20(2)46(86)73-33(22(4)78)48(88)65-10-7-31-70-27(17-97-31)51-71-26(16-98-51)47(87)64-8-5-6-9-66-54(60)61/h13,16-18,20-24,28-29,33-42,52-53,67,76-78,80-84H,5-12,14-15,56H2,1-4H3,(H2,57,79)(H2,59,85)(H2,62,91)(H,63,68)(H,64,87)(H,65,88)(H,69,90)(H,73,86)(H,74,89)(H2,58,72,75)(H4,60,61,66)/t20-,21+,22+,23-,24-,28-,29+,33-,34-,35-,36+,37+,38-,39-,40-,41-,42-,52+,53-/m0/s1

InChI key: InChIKey=NBLHOLNNKJBEDC-XOGQCRKLSA-N

SMILES: [C@H]([C@H](NC(=O)C1=NC([C@@H](NC[C@@H](C(N)=O)N)CC(N)=O)=NC(N)=C1C)C(N[C@@H]([C@H]([C@@H](C(N[C@H](C(NCCC2=NC(=CS2)C3=NC(C(NCCCCNC(=N)N)=O)=CS3)=O)[C@@H](C)O)=O)C)O)C)=O)(O[C@H]4[C@@H](O[C@@H]5[C@@H](O)[C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@H](CO)O4)C6=CN=CN6

Synonyms:

• 2-({2-[2-{[(6-amino-2-{3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl}-5-methylpyrimidin-4-yl)carbonyl]amino}-3-[(5-{[1-({2-[4-({4-[(diaminomethylidene)amino]butyl}carbamoyl)-2,4'-bi-1,3-thiazol-2'-yl]ethyl}amino)-3-hydroxy-1-oxobutan-2-yl]amino}-3-hydroxy-4-methyl-5-oxopentan-2-yl)amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl}oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl carbamate (non-preferred name)
• Bleomycin B(sub 2)
• Bleomycin B₂
• Bleomycinamide, N(sup 1)-(4-((aminoiminomethyl)amino)butyl)-
• Bleomycinamide, N1-(4-((aminoiminomethyl)amino)butyl)-
• Bleomycinamide, N¹-[4-[(aminoiminomethyl)amino]butyl]-
• Brn 0973538
• Dehydrophleomycin D1
• Dehydrophleomycin D₁
• N1-(4-((Aminoiminomethyl)amino)butyl)bleomycinamide
• N¹-[4-[(Aminoiminomethyl)amino]butyl]bleomycinamide
• Phleomycin D2
• Unii-M62Kk37O40
• Zhengguangmycin B₂

Bleomycin B2

CAS: 9060-10-0

Bleomycin B2 is an anticancer drug that has been shown to be effective against various types of tumors. It works by inhibiting kinases and cyclin-dependent inhibitors, which are essential for cancer cell growth and division. Bleomycin B2 induces apoptosis in cancer cells, leading to their death. This drug has been tested on Chinese hamster ovary cells and human tumor cell lines, where it was found to be a potent inhibitor of protein synthesis. Bleomycin B2 is an analog of the natural product bleomycin, which is produced by Streptomyces verticillus. It is excreted in urine after administration and can be used as a marker for monitoring the effectiveness of treatment.

Formula: C₅₅H₈₄N₂₀O₂₁S₂

Purity: Min. 95%

Molecular weight: 1,425.5 g/mol

Ref: 3D-JAA06010

Bleomycin B2

CAS: 9060-10-0

Formula: C₅₅H₈₄N₂₀O₂₁S₂

Molecular weight: 1425.5

Ref: ST-EA-CP-B126003