CAS 90660-20-1

(9cis,13cis)-4,4-difluororetinoic acid

Description:

(9cis,13cis)-4,4-Difluororetinoic acid is a synthetic derivative of retinoic acid, characterized by the presence of two fluorine atoms at the 4-position of the retinoid backbone. This compound is notable for its structural modifications, which influence its biological activity and interaction with retinoic acid receptors. It typically exhibits a high degree of lipophilicity, allowing it to easily permeate cellular membranes. The cis configurations at the 9 and 13 positions contribute to its unique conformational properties, which can affect its binding affinity and efficacy in biological systems. (9cis,13cis)-4,4-Difluororetinoic acid is primarily studied for its potential therapeutic applications in dermatology and oncology, particularly in the modulation of gene expression related to cell differentiation and proliferation. Its fluorinated structure may enhance stability and bioavailability compared to non-fluorinated analogs. As with many retinoids, it may also exhibit side effects, necessitating careful consideration in therapeutic contexts.

Formula: C₂₀H₂₆F₂O₂

InChI: InChI=1/C20H26F2O2/c1-14(7-6-8-15(2)13-18(23)24)9-10-17-16(3)20(21,22)12-11-19(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,23,24)/b8-6+,10-9+,14-7-,15-13-