CAS 906673-24-3
:Crisaborole
Description:
Crisaborole is a topical medication primarily used for the treatment of mild to moderate atopic dermatitis, commonly known as eczema. It is classified as a phosphodiesterase 4 (PDE4) inhibitor, which works by reducing inflammation and modulating the immune response in the skin. The chemical formula of crisaborole is C17H16N2O3, and it has a molecular weight of approximately 284.32 g/mol. This substance appears as a white to off-white solid and is typically formulated as an ointment for topical application. Crisaborole is known for its favorable safety profile, with minimal systemic absorption, making it suitable for long-term use in pediatric and adult populations. Its mechanism of action involves the inhibition of PDE4, leading to increased levels of cyclic adenosine monophosphate (cAMP), which helps to reduce inflammatory cytokine production. Overall, crisaborole represents a novel approach to managing atopic dermatitis, providing an alternative to traditional corticosteroid treatments.
Formula:C14H10BNO3
InChI:InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
InChI key:InChIKey=USZAGAREISWJDP-UHFFFAOYSA-N
SMILES:OB1C=2C(=CC(OC3=CC=C(C#N)C=C3)=CC2)CO1
Synonyms:- 4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile
- 4-[(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile
- An 2728
- An2728
- Benzonitrile, 4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-
- Crisaborole
- Eucrisa
- Staquis
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 9 products.
5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole
CAS:Formula:C14H10BNO3Purity:97%Color and Shape:SolidMolecular weight:251.04514-((1-Hydroxy-1,3-Dihydrobenzo[C][1,2]Oxaborol-5-Yl)Oxy)Benzonitrile
CAS:4-((1-Hydroxy-1,3-Dihydrobenzo[C][1,2]Oxaborol-5-Yl)Oxy)BenzonitrilePurity:99%Molecular weight:251.05g/molCrisaborole-d4
CAS:Formula:C14H6D4BNO3Color and Shape:White To Off-White SolidMolecular weight:255.07Crisaborole
CAS:<p>Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.</p>Formula:C14H10BNO3Purity:99.70%Color and Shape:SolidMolecular weight:251.05Crisaborole
CAS:<p>Crisaborole is a topical antimicrobial peptide that was approved by the FDA in 2017 for the treatment of mild to moderate atopic dermatitis and eczema. It belongs to a class of drugs called small-molecule inhibitors of phosphodiesterase 4 (PDE4). PDE4 is an enzyme that hydrolyzes cyclic adenosine monophosphate (cAMP) and thereby reduces the levels of cAMP in cells. Crisaborole binds to the PDE4 enzyme and blocks its activity, leading to an increase in the level of cAMP. This increased concentration of cAMP leads to suppression of inflammation, which is a major symptom associated with skin diseases such as dermatitis and eczema.</p>Formula:C14H10BNO3Purity:Min. 95%Color and Shape:PowderMolecular weight:251.05 g/mol4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile
CAS:Formula:C14H10BNO3Purity:97%Color and Shape:SolidMolecular weight:251.05
![4-((1-Hydroxy-1,3-Dihydrobenzo[C][1,2]Oxaborol-5-Yl)Oxy)Benzonitrile](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR1011082.jpg&w=3840&q=75)
![4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb%2FF229171.jpg&w=3840&q=75)
