CAS 906673-24-3: Crisaborole

Description:Crisaborole is a topical medication primarily used for the treatment of mild to moderate atopic dermatitis, commonly known as eczema. It is classified as a phosphodiesterase 4 (PDE4) inhibitor, which works by reducing inflammation and modulating the immune response in the skin. The chemical formula of crisaborole is C17H16N2O3, and it has a molecular weight of approximately 284.32 g/mol. This substance appears as a white to off-white solid and is typically formulated as an ointment for topical application. Crisaborole is known for its favorable safety profile, with minimal systemic absorption, making it suitable for long-term use in pediatric and adult populations. Its mechanism of action involves the inhibition of PDE4, leading to increased levels of cyclic adenosine monophosphate (cAMP), which helps to reduce inflammatory cytokine production. Overall, crisaborole represents a novel approach to managing atopic dermatitis, providing an alternative to traditional corticosteroid treatments.

Formula:C₁₄H₁₀BNO₃

InChI:InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2

InChI key:InChIKey=USZAGAREISWJDP-UHFFFAOYSA-N

SMILES:N#CC1=CC=C(OC2=CC=C3B(O)OCC3=C2)C=C1

Synonyms:
4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile
4-[(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl)oxy]benzonitrile
An 2728
An2728
Benzonitrile, 4-[(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]-
Crisaborole
Eucrisa
Staquis

Found 9 products.

Product data	Purity	Price range	Estimated delivery
5-(4-cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole REF: IN-DA00GU0UCAS: 906673-24-3	98%	To inquire	Tue 29 Apr 25
4-((1-Hydroxy-1,3-Dihydrobenzo[C][1,2]Oxaborol-5-Yl)Oxy)Benzonitrile REF: 54-OR1011082CAS: 906673-24-3	99%	37.00 €~1,165.00 €	Mon 28 Apr 25
Crisaborole REF: 54-BUP14505CAS: 906673-24-3	≥98%	84.00 €~356.00 €	Mon 28 Apr 25
Crisaborole REF: 4Z-C-278001CAS: 906673-24-3	- - -	To inquire	Mon 28 Apr 25
Crisaborole-d4 REF: 4Z-C-278002CAS: 906673-24-3	- - -	To inquire	Mon 28 Apr 25
4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile REF: 10-F229171CAS: 906673-24-3	95.0%	39.00 €~1,006.00 €	Wed 30 Apr 25
Crisaborole REF: TM-T4285CAS: 906673-24-3	99.70%	46.00 €~109.00 €	Tue 06 May 25
Crisaborole REF: TR-H947928CAS: 906673-24-3	- - -	135.00 €~452.00 €	Wed 07 May 25
Crisaborole REF: 3D-FC166718CAS: 906673-24-3	Min. 95%	143.00 €~657.00 €	Thu 08 May 25