CAS 90719-30-5

Locostatin

Description:

Locostatin, with the CAS number 90719-30-5, is a chemical compound that has garnered interest primarily for its potential applications in medicinal chemistry, particularly in the context of cancer research. It is classified as a small molecule inhibitor, specifically targeting certain enzymes involved in cellular processes. The compound exhibits characteristics typical of many small molecule inhibitors, including the ability to modulate biological pathways by interfering with enzyme activity. Locostatin's structure includes functional groups that contribute to its binding affinity and specificity for its target, which is crucial for its efficacy in therapeutic applications. Additionally, studies have indicated that it may possess anti-proliferative properties, making it a candidate for further investigation in the development of cancer treatments. As with many compounds in this category, understanding its pharmacokinetics, toxicity, and mechanism of action is essential for evaluating its potential as a therapeutic agent. Further research is necessary to fully elucidate its biological effects and optimize its use in clinical settings.

Formula: C₁₄H₁₅NO₃

InChI: InChI=1S/C14H15NO3/c1-2-6-13(16)15-12(10-18-14(15)17)9-11-7-4-3-5-8-11/h2-8,12H,9-10H2,1H3/b6-2+/t12-/m0/s1

InChI key: InChIKey=UTZAFVPPWUIPBH-QSLRECBCSA-N

SMILES: C([C@@H]1N(C(/C=C/C)=O)C(=O)OC1)C2=CC=CC=C2

Synonyms:

• (4S)-3-[(2E)-1-Oxo-2-buten-1-yl]-4-(phenylmethyl)-2-oxazolidinone
• 2-Oxazolidinone, 3-[(2E)-1-oxo-2-butenyl]-4-(phenylmethyl)-, (4S)-
• 2-Oxazolidinone, 3-(1-oxo-2-butenyl)-4-(phenylmethyl)-, [S-(E)]-
• 2-Oxazolidinone, 3-[(2E)-1-oxo-2-buten-1-yl]-4-(phenylmethyl)-, (4S)-
• UIC 1005

(N-Crotonyl)-(4S)-Isopropyl-2-Oxazolidinone

CAS: 90719-30-5

Formula: C₁₄H₁₅NO₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 245.2738

Ref: IN-DA006B1T

(S,E)-4-Benzyl-3-(But-2-Enoyl)Oxazolidin-2-One

CAS: 90719-30-5

(S,E)-4-Benzyl-3-(But-2-Enoyl)Oxazolidin-2-One

Purity: 98%

Molecular weight: 245.27g/mol

Ref: 54-OR1008812

Locostatin

CAS: 90719-30-5

Locostatin is a small molecule that inhibits the activation of MAPKs by their upstream kinases, thereby suppressing the proliferation and inflammation of cells. Locostatin also suppresses collagen production in fibroblasts, which may be due to its inhibition of MAPK activation. In addition, locostatin inhibits lipid peroxidation and mitochondrial membrane potential in hepatic tissues. This drug has been shown to inhibit the proliferation of T-cells in vitro and to suppress the autoimmune response in animal models. Locostatin also has anti-tuberculosis activity and can be used for treatment of tuberculosis infection. It is not active against Mycobacterium tuberculosis or Mycobacterium avium complex.

Formula: C₁₄H₁₅NO₃

Purity: Min. 95%

Molecular weight: 245.27 g/mol

Ref: 3D-QDA71930