CAS 90729-42-3

Carebastine

Description:

Carebastine is an antihistamine primarily used for the treatment of allergic conditions, such as allergic rhinitis and urticaria. It is a second-generation antihistamine, which means it is designed to minimize sedation and central nervous system effects compared to first-generation antihistamines. Carebastine functions by selectively antagonizing peripheral H1 receptors, thereby inhibiting the action of histamine, a key mediator in allergic responses. The substance is characterized by its relatively long half-life, allowing for once-daily dosing in clinical settings. Carebastine is typically administered in its active form, as it is a metabolite of the prodrug ebastine. Its pharmacokinetics indicate good oral bioavailability, and it is generally well-tolerated, with a lower incidence of side effects such as drowsiness. Carebastine is not associated with significant anticholinergic effects, making it a preferred choice for patients who may be sensitive to such side effects. Overall, it represents a valuable option in the management of allergic symptoms.

Formula: C₃₂H₃₇NO₄

InChI: InChI=1S/C32H37NO4/c1-32(2,31(35)36)27-17-15-24(16-18-27)29(34)14-9-21-33-22-19-28(20-23-33)37-30(25-10-5-3-6-11-25)26-12-7-4-8-13-26/h3-8,10-13,15-18,28,30H,9,14,19-23H2,1-2H3,(H,35,36)

InChI key: InChIKey=XGHOVGYJHWQGCC-UHFFFAOYSA-N

SMILES: C(OC1CCN(CCCC(=O)C2=CC=C(C(C(O)=O)(C)C)C=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4

Synonyms:

• 2-(4-(4-(4-(Benzhydryloxy)piperidin-1-yl)-butanoyl)phenyl)-2-methylpropanoic acid
• 2-(4-(4-(4-Benzhydryloxypiperidino)butyryl)phenyl)-2-methylpropionsaeure
• 2-(4-{4-[4-(Diphenylmethoxy)Piperidin-1-Yl]Butanoyl}Phenyl)-2-Methylpropanoic Acid
• 4-[4-[4-(Diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid
• Benzeneacetic acid, 4-(4-(4-(diphenylmethoxy)-1-piperidinyl)-1-oxobutyl)-alpha,alpha-dimethyl-
• Benzeneacetic acid, 4-[4-[4-(diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-α,α-dimethyl-
• Carebastina
• Carebastina [Spanish]
• Carebastine [INN]
• Carebastinum
• Carebastinum [Latin]
• Unii-75Dln707Do
• p-(4-(4-(Diphenylmethoxy)piperidino)butyryl)-alpha-methylhydratropic acid

Carebastine

CAS: 90729-42-3

Formula: C₃₂H₃₇NO₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 499.6405

Ref: IN-DA00GWX1

Carebastine

CAS: 90729-42-3

Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.

Formula: C₃₂H₃₇NO₄

Purity: 99.16%

Color and Shape: Off-White Solid

Molecular weight: 499.64

Ref: TM-T10680

Carebastine

CAS: 90729-42-3

Formula: C₃₂H₃₇NO₄

Color and Shape: White To Off-White Solid

Molecular weight: 499.65

Ref: 4Z-C-461

Carebastine

CAS: 90729-42-3

Carebastine

Purity: ≥98%

Molecular weight: 499.64g/mol

Ref: 54-BUP02159

Carebastine

CAS: 90729-42-3

Carebastine

Formula: C₃₂H₃₇NO₄

Purity: 95%

Color and Shape: white solid

Molecular weight: 499.65g/mol

Ref: 54-OR928627

Carebastine

Controlled Product

CAS: 90729-42-3

Applications The active carboxylic acid metabolite of Ebastine.
References Hashizume, T., et al.: Drug Metab. Dispos., 29, 798 (2001), Hashizume, T., et al.: J. Pharmacol. Exp. Ther., 300, 298 (2002), Matsumoto, S., et al.: Xenobiotica, 33, 615 (2003), Chaikin, P., et al.: Br. J. Clin. Pharmacol., 59, 346 (2005),

Formula: C₃₂H₃₇NO₄

Color and Shape: Neat

Molecular weight: 499.64

Ref: TR-C183440

Carebastine

CAS: 90729-42-3

Purity: 95%

Molecular weight: 499.651000976563

Ref: 10-F796580

Carebastine

CAS: 90729-42-3

Carebastine is a histamine H1 receptor antagonist. Carebastine blocks the action of histamine on cells that release inflammatory substances and is used to treat allergic symptoms such as itching, sneezing, and runny nose. Carebastine has been shown to reduce the frequency of bowel movements in patients with chronic idiopathic constipation. This drug can also cause side effects such as drowsiness, dry mouth, headache, blurred vision, muscle weakness and pain.

Formula: C₃₂H₃₇NO₄

Purity: Min. 95%

Molecular weight: 499.64 g/mol

Ref: 3D-FC19812