CAS 9073-95-4

Phosphogluconate dehydrogenase (NADP, decarboxylating)

Description:

Phosphogluconate dehydrogenase (NADP+, decarboxylating), with the CAS number 9073-95-4, is an enzyme that plays a crucial role in the pentose phosphate pathway, a metabolic pathway parallel to glycolysis. This enzyme catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose-5-phosphate, utilizing NADP+ as a cofactor and producing NADPH and carbon dioxide as byproducts. The generation of NADPH is vital for various biosynthetic reactions and for maintaining the cellular redox state. The enzyme is typically found in various organisms, including bacteria and eukaryotes, and is essential for cellular metabolism, particularly in tissues with high anabolic activity. Its activity can be influenced by factors such as substrate concentration, pH, and temperature. Understanding the characteristics and functions of phosphogluconate dehydrogenase is important for insights into metabolic regulation and potential therapeutic targets in metabolic disorders.

Formula: Unspecified

Synonyms:

• 6-Phosphogluconate dehydrogenase (decarboxylating)
• Phosphogluconate dehydrogenase (decarboxylating)
• Dehydrogenase, phosphogluconate (decarboxylating)
• E.C. 1.1.1.44
• Phosphogluconate dehydrogenase (NADP, decarboxylating)

6-Phosphogluconic dehydrogenase from yeast

CAS: 9073-95-4

6-Phosphogluconic dehydrogenase is an enzyme from yeast, which is a key component of the oxidative phase of the pentose phosphate pathway. It catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate, with the concurrent reduction of NADP+ to NADPH. This enzyme is sourced from yeast, a model organism extensively used in biochemical studies due to its eukaryotic nature and ease of genetic manipulation.

Purity: Min. 95%

Ref: 3D-JAA07395