γ-Glutamyl hydrolase, also known as γ-glutamyltransferase (GGT), is an enzyme that plays a crucial role in the metabolism of glutathione and the transfer of γ-glutamyl groups between molecules. It is primarily found in the liver, kidneys, and pancreas, and is involved in the degradation of extracellular glutathione, facilitating the transport of amino acids across cell membranes. The enzyme catalyzes the hydrolysis of γ-glutamyl compounds, contributing to various physiological processes, including antioxidant defense and amino acid homeostasis. γ-Glutamyl hydrolase is also significant in clinical diagnostics, as elevated levels of this enzyme in serum can indicate liver dysfunction, biliary obstruction, or other pathological conditions. The enzyme operates optimally at physiological pH and temperature, and its activity can be influenced by various factors, including substrate concentration and the presence of inhibitors or activators. Understanding the characteristics and functions of γ-glutamyl hydrolase is essential for both biochemical research and clinical applications.

γ-Glutamyl hydrolase

9074-87-7: γ-Glutamyl hydrolase, also known as γ-glutamyltransferase (GGT), is an enzyme that plays a crucial role in the metabolism of glutathione and the transfer of γ-glutamyl groups between molecules. It is primarily found in the liver, kidneys, and pancreas, and is involved in the degradation of extracellular glutathione, facilitating the transport of amino acids across cell membranes. The enzyme catalyzes the hydrolysis of γ-glutamyl compounds, contributing to various physiological processes, including antioxidant defense and amino acid homeostasis. γ-Glutamyl hydrolase is also significant in clinical diagnostics, as elevated levels of this enzyme in serum can indicate liver dysfunction, biliary obstruction, or other pathological conditions. The enzyme operates optimally at physiological pH and temperature, and its activity can be influenced by various factors, including substrate concentration and the presence of inhibitors or activators. Understanding the characteristics and functions of γ-glutamyl hydrolase is essential for both biochemical research and clinical applications.

<p>Carboxypeptidase G (EC 3.4.17.11, alternative name γ-Glutamyl hydrolase) is a protease that cuts γ-glutamyl bonds with high specificity. One unit of Carboxypeptidase G will hydrolyze (+)amethopterin to generate 1.0 μmole of L-glutamic acid.</p>

CAS 9074-87-7

γ-Glutamyl hydrolase

Carboxypeptidase G from pseudomonas sp.

Ref: 3D-JAA07487