CAS 9076-44-2
:Chymostatin
Description:
Chymostatin is a potent and selective inhibitor of serine proteases, particularly targeting chymotrypsin and related enzymes. It is a natural product derived from the fermentation of certain actinomycetes, specifically Streptomyces species. Chymostatin exhibits a unique structure that allows it to bind effectively to the active site of serine proteases, thereby preventing substrate access and inhibiting enzymatic activity. This characteristic makes it a valuable tool in biochemical research for studying protease functions and mechanisms. Additionally, chymostatin has been investigated for its potential therapeutic applications, particularly in cancer research, due to its ability to modulate proteolytic processes involved in tumor progression and metastasis. The compound is typically used in laboratory settings, and its effectiveness can vary based on the specific protease being studied. As with many protease inhibitors, careful consideration of concentration and experimental conditions is essential for optimal results in research applications.
Formula:Unspecified
InChI:InChI=1/2C31H41N7O6.C30H39N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21;1-3-19(2)25(27(40)34-22(18-39)16-20-10-6-4-7-11-20)37-28(41)26(23-14-15-33-30(32)35-23)38-31(44)36-24(29(42)43)17-21-12-8-5-9-13-21;1-18(2)24(26(39)33-21(17-38)15-19-9-5-3-6-10-19)36-27(40)25(22-13-14-32-29(31)34-22)37-30(43)35-23(28(41)42)16-20-11-7-4-8-12-20/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44);4-13,18-19,22-26H,3,14-17H2,1-2H3,(H,34,40)(H,37,41)(H,42,43)(H3,32,33,35)(H2,36,38,44);3-12,17-18,21-25H,13-16H2,1-2H3,(H,33,39)(H,36,40)(H,41,42)(H3,31,32,34)(H2,35,37,43)/t22-,23?,24-,25-,26-;19-,22-,23?,24-,25-,26-;21-,22?,23-,24-,25-/m000/s1
SMILES:CC(C)C[C@@H](C(=N[C@@H](Cc1ccccc1)C=O)O)N=C([C@H](C1CCNC(=N)N1)NC(=N[C@@H](Cc1ccccc1)C(=O)O)O)O.CC[C@H](C)[C@@H](C(=N[C@@H](Cc1ccccc1)C=O)O)N=C([C@H](C1CCNC(=N)N1)NC(=N[C@@H](Cc1ccccc1)C(=O)O)O)O.CC(C)[C@@H](C(=N[C@@H](Cc1ccccc1)C=O)O)N=C([C@H](C1CCNC(=N)N1)NC(=N[C@@H](Cc1ccccc1)C(=O)O)O)O
Synonyms:- Chymostatin
- N-{[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-{[(2S)-4-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenylpropan-2-yl]amino}pentan-2-yl]amino}-2-oxoethyl]carbamoyl}-L-phenylalanine
- (2S)-2-[[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(1S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid
- (2S)-2-[[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(1S,2S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-2-methyl-butyl]amino]-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid
- (2S)-2-[[(1S)-1-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-2-[[(1S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]amino]-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid
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Found 7 products.
Chymostatin (microbial product)
CAS:The microbial product is a mixture of the chymostatins A, B, and C. It inhibits most cysteine proteases, especially chymotrypsin. Chymostatin is often applied for inhibiting chymase.Color and Shape:White PowderChymostatin
CAS:<p>Chymostatin is a protein that inhibits the polymerase chain reaction (PCR) by binding to the DNA polymerase. It has been shown to have a hypoglycemic effect in mice with myocardial infarcts and can also induce apoptosis in inflammatory lesions. Chymostatin binds to intracellular targets, such as cell factor and pro-apoptotic protein, which are involved in energy metabolism and inflammatory lesion. The inhibition of these targets may be due to its chemical biology properties, which include the formation of disulfide bonds and basic proteins. Chymostatin is not active against bacterial cells but can inhibit enzyme activities in mammalian cells.</p>Formula:C31H42N6O7Purity:Min. 95%Molecular weight:610.71 g/molChymostatin
CAS:<p>Inhibitor of chymotrypsin</p>Formula:C31H41N7O6Color and Shape:White To Yellowish SolidMolecular weight:607.7 g/molChymostatin (0.5 mg vial)
CAS:<p>Chymostatin is a protein-based inhibitor that binds to the receptor site of amyloid beta peptides, preventing them from aggregating and thereby inhibiting the formation of amyloid plaques. It has been shown that chymostatin inhibits ion channels, ligand-gated channels, and voltage-gated channels. Chymostatin is a high purity product with an average purity of 99% by HPLC analysis. It is also available in a variety of concentrations (0.5 mg vial).</p>Formula:C31H42N6O7Purity:Min. 95%Molecular weight:610.72 g/mol
