CAS 908846-88-8

N-Fmoc-5-fluoro-L-tryptophan

Description:

N-Fmoc-5-fluoro-L-tryptophan is a derivative of the amino acid tryptophan, characterized by the presence of a fluoro group at the 5-position of the indole ring and a fluorenylmethyloxycarbonyl (Fmoc) protective group on the amino group. This compound is typically used in peptide synthesis, particularly in solid-phase peptide synthesis, due to the stability of the Fmoc group under basic conditions, allowing for selective deprotection. The introduction of the fluorine atom can enhance the compound's biological activity and influence its interactions with biological targets. N-Fmoc-5-fluoro-L-tryptophan is often utilized in research settings to study protein structure and function, as well as in the development of pharmaceuticals. Its unique properties, including its ability to participate in hydrogen bonding and its hydrophobic character, make it a valuable building block in the design of novel peptides and proteins. As with many fluorinated compounds, it may exhibit altered solubility and reactivity compared to its non-fluorinated counterparts.

Fmoc-5-fluoro-L-tryptophan

CAS: 908846-88-8

Formula: C₂₆H₂₁FN₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 444.4543

Ref: IN-DA00GWA3

Fmoc-L-5-fluoroTryptophan

CAS: 908846-88-8

Fmoc-L-5-fluoroTryptophan

Purity: 98%

Molecular weight: 444.46g/mol

Ref: 54-PC99745

N-Fmoc-5-fluoro-L-tryptophan

CAS: 908846-88-8

N-Fmoc-5-fluoro-L-tryptophan is a biologically active form of tryptophan that has been shown to have potent effects on the cardiovascular system. It is used as a tool for studying the function of angiotensin, collagen, and microstructural elements in the heart and lungs. N-Fmoc-5-fluoro-L-tryptophan has been shown to synergize with other heterocycles, maximizing its biological properties. This chemical is also effective at inducing muscle contraction in rats. N-Fmoc-5-fluoro-L-tryptophan binds to cardiothoracic proteins, causing changes in their structure that lead to increased muscle contractility. The covalent bond between this compound and the protein can be cleaved by enzymes such as proteases or nucleases, which can be useful for studying the interactions of drugs with these proteins.

Formula: C₂₆H₂₁FN₂O₄

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 444.45 g/mol

Ref: 3D-FF79054

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-fluoro-1H-indol-3-yl)propanoic acid

CAS: 908846-88-8

Formula: C₂₆H₂₁FN₂O₄

Purity: 98%

Molecular weight: 444.462

Ref: 10-F549448

N-Fmoc-5-fluoro-L-tryptophan

Controlled Product

CAS: 908846-88-8

Applications N-Fmoc-5-fluoro-L-tryptophan is a protected form of 5-fluoro-L-tryptophan, a compound that selectively binds to human serum albumin (HSA), the most abundant protein in the circulatory system. 5-Fluoro-L-tryptophan is also a derivative of L-Tryptophan is an amino acid that is a metabolic precursor of Norepinephrine (N674500) and Serotonin (S274980).
References Bunney, W., et al.: Am. J. Psych., 127, 872 (1971); Chanut, E., et al.: Biochem. Pharma., 44, 2082 (1992); Gerig, J. & Klinkenborg, J.: J. Am. Chem. Soc., 102, 4267 (1980)

Formula: C₂₆H₂₁FN₂O₄

Color and Shape: Neat

Molecular weight: 444.454

Ref: TR-F622905