CAS 909-14-8

(-)-Calanolide B

Description:

(-)-Calanolide B is a naturally occurring compound classified as a sesquiterpene lactone, derived from the tropical tree Calophyllum lanigerum. It is known for its unique structural features, which include a bicyclic framework and a lactone functional group. This compound exhibits a range of biological activities, including anti-inflammatory and antiviral properties, making it of interest in pharmaceutical research. (-)-Calanolide B has been studied for its potential as an inhibitor of HIV-1 reverse transcriptase, showcasing its relevance in the development of antiviral therapies. The compound is typically characterized by its specific optical rotation, which reflects its chiral nature, and its solubility in organic solvents. Its molecular formula and weight contribute to its reactivity and interaction with biological systems. As research continues, (-)-Calanolide B may offer insights into new therapeutic avenues, particularly in the context of infectious diseases and inflammation.

Formula: C₂₂H₂₆O₅

InChI: InChI=1S/C22H26O5/c1-6-7-13-10-15(23)26-21-16(13)20-14(8-9-22(4,5)27-20)19-17(21)18(24)11(2)12(3)25-19/h8-12,18,24H,6-7H2,1-5H3/t11-,12-,18-/m0/s1

InChI key: InChIKey=NIDRYBLTWYFCFV-PZROIBLQSA-N

SMILES: C(CC)C=1C2=C(C3=C(C4=C2OC(C)(C)C=C4)O[C@@H](C)[C@H](C)[C@@H]3O)OC(=O)C1

Synonyms:

• (10S,11R,12S)-11,12-Dihydro-12-hydroxy-6,6,10,11-tetramethyl-4-propyl-2H,6H,10H-benzo[1,2-b:3,4-b′:5,6-b′′]tripyran-2-one
• 2H,8H-Benzo[1,2-b:3,4-b′]dipyran-6-acrylic acid, 3,4-dihydro-4,5-dihydroxy-2,3,8,8-tetramethyl-β-propyl-, δ-lactone
• NSC 661122
• 2H,6H,10H-Benzo[1,2-b:3,4-b′:5,6-b′′]tripyran-2-one, 11,12-dihydro-12-hydroxy-6,6,10,11-tetramethyl-4-propyl-, (10S,11R,12S)-
• 2H,6H,10H-Benzo[1,2-b:3,4-b′:5,6-b′′]tripyran-2-one, 11,12-dihydro-12-hydroxy-6,6,10,11-tetramethyl-4-propyl-, [10S-(10α,11β,12β)]-

Costatolide

CAS: 909-14-8

Costatolide, from Calophyllum spp., is an HIV-1 inhibitor and plant-derived delta-lactone with anti-HIV activity.

Formula: C₂₂H₂₆O₅

Color and Shape: Solid

Molecular weight: 370.44

Ref: TM-T68387