CymitQuimica logo

CAS 909024-55-1

:

DOTA-cyclo(RGDfK) acetate

Description:
DOTA-cyclo(RGDfK) acetate is a synthetic compound that combines the chelating agent DOTA (1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid) with a cyclic peptide, cyclo(RGDfK), which is known for its affinity to integrin receptors, particularly αvβ3 integrins. This compound is primarily utilized in biomedical applications, especially in targeted imaging and therapy in oncology, due to its ability to selectively bind to tumor cells that overexpress integrins. The DOTA moiety allows for the coordination of radiometals, making it suitable for radiolabeling in positron emission tomography (PET) or single-photon emission computed tomography (SPECT). The acetate group enhances the solubility and stability of the compound in physiological conditions. Overall, DOTA-cyclo(RGDfK) acetate is characterized by its high specificity for integrin receptors, its chelating properties, and its potential for use in diagnostic and therapeutic applications in cancer treatment.
Formula:C43H67N13O14
Synonyms:
  • Cyclo[L-arginylglycyl-L-a-aspartyl-Dphenylalanyl-N6-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-L-lysyl]
  • DOTA-cyclo(RGDfK) acetate
  • Cyclo[L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-N6-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-L-lysyl]
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 2 products.