CAS 90954-53-3

calcitonin gene related peptide human

Description:

Calcitonin gene-related peptide (CGRP) is a neuropeptide that plays a significant role in various physiological processes, particularly in the nervous system and cardiovascular regulation. It is derived from the calcitonin gene and is primarily involved in vasodilation and the transmission of pain signals. CGRP is composed of a sequence of amino acids, making it a peptide, and it exists in two isoforms: alpha and beta, with the alpha form being predominant in humans. The peptide is known for its potent vasodilatory effects, which contribute to its role in migraine pathophysiology. CGRP is also implicated in inflammatory responses and has been studied for its potential therapeutic applications in conditions such as migraines and other pain disorders. Its biological activity is mediated through specific receptors, known as CGRP receptors, which are G protein-coupled receptors. The CAS number 90954-53-3 uniquely identifies this substance in chemical databases, facilitating research and development in pharmacology and biochemistry.

Formula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

InChI: InChI=1/C163H269N51O49S2/c1-73(2)52-97(186-116(226)65-179-131(233)82(18)183-139(241)98(53-74(3)4)193-137(239)94(44-35-49-176-162(171)172)188-142(244)101(57-91-62-175-72-182-91)199-159(261)128(88(24)221)213-156(258)123(79(13)14)207-151(253)110(71-265)204-160(262)126(86(22)219)210-133(235)84(20)185-157(259)125(85(21)218)211-147(249)105(61-119(229)230)198-150(252)109(70-264)203-130(232)81(17)166)140(242)194-99(54-75(5)6)141(243)202-108(69-217)149(251)190-95(45-36-50-177-163(173)174)138(240)201-106(67-215)134(236)180-63-115(225)178-64-118(228)205-121(77(9)10)155(257)208-122(78(11)12)154(256)191-93(43-32-34-48-165)136(238)196-102(58-112(167)222)144(246)197-103(59-113(168)223)143(245)195-100(56-90-40-29-26-30-41-90)145(247)209-124(80(15)16)161(263)214-51-37-46-111(214)152(254)212-127(87(23)220)158(260)200-104(60-114(169)224)146(248)206-120(76(7)8)153(255)181-66-117(227)187-107(68-216)148(250)189-92(42-31-33-47-164)135(237)184-83(19)132(234)192-96(129(170)231)55-89-38-27-25-28-39-89/h25-30,38-41,62,72-88,92-111,120-128,215-221,264-265H,31-37,42-61,63-71,164-166H2,1-24H3,(H2,167,222)(H2,168,223)(H2,169,224)(H2,170,231)(H,175,182)(H,178,225)(H,179,233)(H,180,236)(H,181,255)(H,183,241)(H,184,237)(H,185,259)(H,186,226)(H,187,227)(H,188,244)(H,189,250)(H,190,251)(H,191,256)(H,192,234)(H,193,239)(H,194,242)(H,195,245)(H,196,238)(H,197,246)(H,198,252)(H,199,261)(H,200,260)(H,201,240)(H,202,243)(H,203,232)(H,204,262)(H,205,228)(H,206,248)(H,207,253)(H,208,257)(H,209,247)(H,210,235)(H,211,249)(H,212,254)(H,213,258)(H,229,230)(H4,171,172,176)(H4,173,174,177)/t81-,82-,83-,84-,85+,86+,87+,88+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-,124-,125-,126-,127-,128-/m0/s1

Synonyms:

• Calcitonin Gene-Related Peptide-I, Human
• Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-Nh2

Calcitonin Gene Related Peptide, Human

CAS: 90954-53-3

For cellular and molecular biology applications

Formula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Molecular weight: 3789.3

Ref: 02-J65667

α-CGRP (human)

CAS: 90954-53-3

Bachem ID: 4013281.

Formula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Purity: 97.62%

Color and Shape: White

Molecular weight: 3789.36

Ref: 01-4013281

α-CGRP(human)

CAS: 90954-53-3

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.

Formula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 3789.33

Ref: TM-TP2044

CGRP (Human)

CAS: 90954-53-3

Human CGRP with a disulfide bond between Cys2-Cys7 and available as a 0.1mg vial. CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide that is found in humans and is widely distributed in the nervous system, particularly in sensory neurons, and is involved in the regulation of vascular tone, blood flow, pain perception, and inflammation. It is a potent vasodilator and has been implicated in the pathophysiology of several vascular disorders, including migraine headaches, cluster headaches, and hypertension.
In addition to its vascular effects, human CGRP also has neuroprotective properties and has been investigated as a potential therapeutic agent for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
Human CGRP has been extensively studied as a research tool to investigate its physiological and pathological roles in various tissues and diseases. It has also been targeted by pharmacological agents, such as CGRP antagonists and antibodies, for the treatment of migraine headaches and other conditions associated with CGRP dysfunction.

Formula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Purity: Min. 95%

Molecular weight: 3,789.3 g/mol

Ref: 3D-PCG-4160-S

CGRP (Human)

CAS: 90954-53-3

CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide that is found in humans and is widely distributed in the nervous system, particularly in sensory neurons, and is involved in the regulation of vascular tone, blood flow, pain perception, and inflammation. It is a potent vasodilator and has been implicated in the pathophysiology of several vascular disorders, including migraine headaches, cluster headaches, and hypertension.
In addition to its vascular effects, human CGRP also has neuroprotective properties and has been investigated as a potential therapeutic agent for various neurological disorders, such as Alzheimer's disease and Parkinson's disease.
Human CGRP has been extensively studied as a research tool to investigate its physiological and pathological roles in various tissues and diseases. It has also been targeted by pharmacological agents, such as CGRP antagonists and antibodies, for the treatment of migraine headaches and other conditions associated with CGRP dysfunction.
This product is available as a 0.5mg vial.

Formula: C₁₆₃H₂₆₇N₅₁O₄₉S₂

Purity: Min. 95%

Molecular weight: 3,789.3 g/mol

Ref: 3D-PCG-4160-V