CAS 90961-53-8

Tedisamil

Description:

Tedisamil is a chemical compound that belongs to the class of antiarrhythmic agents, primarily used in the treatment of cardiac arrhythmias. It functions as a potassium channel blocker, specifically targeting the rapid component of the delayed rectifier potassium current (IKr), which plays a crucial role in cardiac repolarization. This mechanism helps to stabilize the cardiac rhythm and prevent abnormal heartbeats. Tedisamil is characterized by its ability to prolong the action potential duration and refractory period in cardiac tissues, making it effective in managing certain types of arrhythmias. The compound has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, which are essential for determining its therapeutic efficacy and safety profile. Additionally, like many pharmacological agents, Tedisamil may exhibit side effects, and its use must be carefully monitored in clinical settings. Overall, Tedisamil represents a significant advancement in the pharmacological management of heart rhythm disorders.

Formula: C₁₉H₃₂N₂

InChI: InChI=1S/C19H32N2/c1-2-8-19(7-1)17-11-20(9-15-3-4-15)12-18(19)14-21(13-17)10-16-5-6-16/h15-18H,1-14H2

InChI key: InChIKey=CTIRHWCPXYGDGF-UHFFFAOYSA-N

SMILES: C(N1CC2C3(C(CN(CC4CC4)C2)C1)CCCC3)C5CC5

Synonyms:

• Tedisamilum [INN-Latin]
• 3′,7′-Bis(cyclopropylmethyl)spiro[cyclopentane-1,9′-[3,7]diazabicyclo[3.3.1]nonane]
• Tedisamilum
• Pulzium
• 3',7'-Bis(cyclopropylmethyl)spiro(cyclopentane-1,9'-(3,7)diazabicyclo(3.3.1)nonane)
• 3,7-bis(cyclopropylmethyl)-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,1'-cyclopentane]
• Tedisamil
• KC 8857
• Tedisamil [INN]
• Spiro(cyclopentane-1,9'-(3,7)diazabicyclo(3.3.1)nonane), 3',7'-bis(cyclopropylmethyl)-
• UNII-A5VAY2U3R8

Tedisamil

CAS: 90961-53-8

Tedisamil blocks cardiac K+ currents, slows heart rate, is a class III antiarrhythmic, and treats angina.

Formula: C₁₉H₃₂N₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 288.47

Ref: TM-T24863